Accumulating evidence indicates that mitotic checkpoint serine/threonine kinase B (BUB1B) plays a critical role in multiple types of cancer. However, the biological function and molecular regulatory mechanism of BUB1B in glioblastoma (GBM) remain unclear. In the present study, we identified that BUB1B expression was enriched in GBM tumors and was functionally required for tumor proliferation bo...

It is a frequent clinical, and less frequent labora tory, observation that a tumor subjected to a number of sublethal irradiations will gradually acquire radioresistance (5, 11). The usual manifes tation of acquired radioresistance by a tumor is the diminished amount of regression for the same dose, or the increased dose required for an equal amount of regression or for sterilization, as the ra...

Gliomas originate from glial cells and are the most frequent primary brain tumors. High-grade gliomas occur ∼4 times more frequently than low-grade gliomas, are highly malignant, and have extremely poor prognosis. Radiotherapy, sometimes combined with chemotherapy, is considered the treatment of choice for gliomas and is used after resective surgery. Despite great technological improvements, th...

It is a frequent clinical, and less frequent labora tory, observation that a tumor subjected to a number of sublethal irradiations will gradually acquire radioresistance (5, 11). The usual manifes tation of acquired radioresistance by a tumor is the diminished amount of regression for the same dose, or the increased dose required for an equal amount of regression or for sterilization, as the ra...

Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs). We find that LIG4, a DNA ligase in DNA double-strand break repair, is a direct target of β-catenin. Wnt signalling enhances non-homologous end-joining repai...

It is a frequent clinical, and less frequent labora tory, observation that a tumor subjected to a number of sublethal irradiations will gradually acquire radioresistance (5, 11). The usual manifes tation of acquired radioresistance by a tumor is the diminished amount of regression for the same dose, or the increased dose required for an equal amount of regression or for sterilization, as the ra...

Radiotherapy (RT) is a key therapeutic strategy for lung cancer, the most common cause of cancer-related deaths worldwide, but radioresistance often occurs and leads to failure of RT. It is therefore important to clarify the mechanism underlying radioresistance in lung cancer. Cancer stem cells (CSCs) are considered the fundamental reason for radioresistance. MicroRNAs (miRNAs) have been regard...

With the development of advanced imaging and radiation technologies, radiotherapy has been employed as the principal treatment approach for nasopharyngeal carcinoma (NPC). So far, a number of patients still suffer from the failure of this treatment due to the acquired radioresistance, but the underlying mechanisms are still poorly defined. In this study, we found that Twist1, participating in a...

Radioresistance remains a major problem in the treatment of patients suffering from nasopharyngeal carcinoma (NPC). A better understanding of the mechanisms of radioresistance may generate new strategies to improve NPC patients' responses to therapy. This study was designed to investigate the effect of microRNA on the radiosensitivity of NPC cells. A microRNA microarray indicated that miR-24 wa...