The exceptional affinity, specificity, and selectivity of antibodies make them extraordinarily attractive vectors for tumor-targeted PET radiopharmaceuticals. Due to their multi-day biological half-life, antibodies must be labeled with positron-emitting radionuclides with relatively long physical decay half-lives. Traditionally, the positron-emitting isotopes 124I (t1/2=4.18 d), 86Y (t1/2=14.7 ...

Serotonergic 5-HT2A receptors in cortical and forebrain regions are an important substrate for the neuromodulatory actions of serotonin brain. They have been implicated etiology many neuropsychiatric disorders serve as a target antipsychotic, antidepressant, anxiolytic drugs. Positron emission tomography imaging using suitable radioligands can be applied vivo quantification receptor densities o...