Designing radiotherapy treatments is a complicated and important task that affects patient care, and modern delivery systems enable a physician more flexibility than can be considered. Consequently, treatment design is increasingly automated by techniques of optimization, and many of the advances in the design process are accomplished by a collaboration among medical physicists, radiation oncol...

Cancer, which is the uncontrolled division of cells, a leading fatal disease in world with high mortality rates. It can be treated using several methods, including radiotherapy, involves ionizing radiation. Radiotherapy on basis source placement has two types, i.e. brachytherapy and external beam radiotherapy. External radiotherapy evolved from 2-D conventional therapy to 3-D Conformal (3D-CRT)...

PURPOSE Inverse planning is trial-and-error iterative process. This work introduces a fully automated inverse optimization approach, where the treatment plan is closely tailored to the unique patient anatomy. The auto-optimization is applied to pancreatic stereotactic body radiotherapy (SBRT). MATERIALS AND METHODS The automation is based on stepwise reduction of dose-volume histograms (DVHs)...

This paper proposes and analyses a mathematical model for the problem of distribution of a finite number of irradiation sources during radiotherapy in continuous environments to maximize the minimal cumulative effects. A new algorithm based on nondifferentiable optimization techniques has been developed to solve this problem.

Background: The standard treatment for locally advanced non-small cell lung cancer (LA-NSCLC) is represented by concomitant chemo-radiotherapy followed consolidation with durvalumab that ensures a 5-year survival of 46%. However, the risk radiotherapy-induced pneumonia (RIP) almost 10–15%. Complete cardiological examination also usually performed during cardiopulmonary pre-treatment evaluation ...

The purpose of this study is to develop a system to automatically generate stowage plan for large containerships. The system consists of three modules: stowage plan generator, stability module and optimization engine. This paper presents the architecture and the work of the first module stowage plan generator, which is used to automatically generate a feasible stowage plan with reasonable crane...

Maintaining high on-time performance and at the same time having high capacity utilization is a challenge for several railway traffic systems. The system becomes sensitive to disturbances and delays are easily propagating in the network. One way to handle this problem is to create more robust timetables; timetables that can absorb delays and prevent them from propagating. This paper presents an...