نتایج جستجو برای: randomized placebo
تعداد نتایج: 282883 فیلتر نتایج به سال:
INTRODUCTION To evaluate the effect of α-lipoic acid (ALA) on the occurrence of diabetic macular edema. METHODS Randomized, double-blind, placebo-controlled, multicenter, multinational study. Patients were randomized to the treatment group with 600 mg ALA per day or the placebo group. Every 6 months stereo fundus photographs, HbA1c levels, and an ophthalmological examination were documented. ...
OBJECTIVE To compare the effectiveness of manual therapy and ultrasound (US) with manual therapy and placebo ultrasound (placebo US) in the treatment of new episodes of unilateral shoulder pain referred for physiotherapy. METHODS In a multicentre, double blind, placebo-controlled randomized trial, participants were recruited with a clinical diagnosis of unilateral shoulder pain from nine prim...
COMFORT-I is a randomized, double-blind, placebo-controlled trial of the Janus kinase 1/Janus kinase 2 inhibitor ruxolitinib in 309 patients with intermediate-2 or high-risk myelofibrosis. This analysis of COMFORT-I describes the long-term efficacy and safety of ruxolitinib (median follow-up, 2 years). Spleen volume was measured by magnetic resonance imaging, and quality of life was evaluated u...
AIMS/INTRODUCTION Asian patients represent a large portion of the global population with type 2 diabetes mellitus, but are underrepresented in trials of glucose-lowering therapies. The present randomized, phase III, placebo-controlled, double-blind, 24-week study evaluated the dipeptidyl peptidase-4 inhibitor, linagliptin, as monotherapy in Asian patients with inadequately controlled type 2 dia...
INTRODUCTION Current smoking cessation guidelines recommend setting a quit date prior to starting pharmacotherapy. However, providing flexibility in the date of quitting may be more acceptable to some smokers. The objective of this study was to compare varenicline 1 mg twice daily (b.i.d.) with placebo in subjects using a flexible quit date paradigm after starting medication. METHODS In this ...
Abstract Background Treatments for MDD that can improve both overall depressive and anhedonic symptoms are urgently needed. AXS-05 (dextromethorphan-bupropion) is a novel, oral, investigational NMDA receptor antagonist with multimodal activity being developed MDD. The dextromethorphan component of an sigma-1 agonist. bupropion serves primarily to increase the bioavailability dextromethorphan. O...
Tezepelumab is a human monoclonal antibody that targets thymic stromal lymphopoietin (TSLP). NAVIGATOR evaluated the efficacy and safety of tezepelumab in adults adolescents with severe, uncontrolled asthma. was phase 3, multicenter, randomized, double-blind, placebo-controlled study (NCT03347279). Patients (12-80 years old) asthma were randomized 1:1 to receive 210mg subcutaneously or placebo ...
Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol efflux, mediated by apolipoprotein A-I, removes excess cholesterol from atherosclerotic plaque and transports it to the liver excretion. Impaired efflux is associated with higher cardiovascular (CV) event rates among both stable coronary artery disease recent MI. CSL112, a novel intravenous formulati...
clonidine has sedative and analgesic properties. randomized studies examining these properties in mechanically ventilated icu patients are scarce. this study was designed to assess the impact of clonidine on sedative agent use in mechanically ventilated patients.in a prospective, randomized, double blind, placebo-controlled study in a general icu of a university medical center in tehran, iran, ...
Background: Individuals living with Alzheimer’s disease (AD) demonstrate extensive deficits in social cognition. To date, no studies have investigated the feasibility of an intranasal oxytocin (INOT) treatment to improve cognition individuals AD. Objective: We conducted a pilot trial determine recruitment feasibility, enrolment acceptability, and adherence INOT inform on subsequent design futur...
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