نتایج جستجو برای: randomized placebo controlled trial
تعداد نتایج: 687100 فیلتر نتایج به سال:
The use of placebo controls in psychiatric research is controversial. In this article, we focus on a troubling Japanese case of a randomized withdrawal trial of the antidepressant sertraline and analyze the ethical issues underlying it. First, we consider whether a placebo-controlled withdrawal trial should, in general, be considered more ethical than a standard placebo-controlled trial. We arg...
Background Endemic goiter is present in most parts of Iran. Iron deficiency adversely affects the physiology of thyroid. The initial steps of thyroid hormone synthesis are catalyzed by thyroperoxidases and are dependent on iron. In many developing countries, children are at high risk of both goiter and iron deficiency anemia. In addition, iron deficiency may alter central nervous system contro...
Methods. This was a randomized, double-blind, placebo-controlled trial. Subjects were randomized to receive either 100 mg of morphine (MS) or placebo (PLCB) with the spinal injection of bupivacaine and fentanyl. Assessments included need for supplementation during labour analgesia, use of pain medications for 24 h after delivery, and side-effects. The primary endpoint was the rate of breakthrou...
BACKGROUND Sample size calculation is a key aspect in the planning of any trial. Planning a randomized placebo-controlled trial in relapsing-remitting multiple sclerosis (RRMS) requires knowledge of the annualized relapse rate (ARR) in the placebo group. OBJECTIVES This paper aims (i) to characterize the uncertainty in ARR by conducting a systematic review of placebo-controlled, randomized tr...
Clonidine has sedative and analgesic properties. Randomized studies examining these properties in mechanically ventilated ICU patients are scarce. This study was designed to assess the impact of clonidine on sedative agent use in mechanically ventilated patients.In a prospective, randomized, double blind, placebo-controlled study in a general ICU of a university medical center in Tehran, Iran, ...
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