نتایج جستجو برای: rara positive apl
تعداد نتایج: 662831 فیلتر نتایج به سال:
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) characterized by a severe bleeding tendency, accumulation of abnormal promyelocytes in the bone marrow and a reciprocal t(15;17) chromosomal translocation that fuses the gene encoding the promyelocytic leukemia protein (PML) to that encoding retinoic acid receptor alpha (RARA) (de Thé & Chen, 2010). During ...
phagic vesicles after treatment with these agents. Functionally, activation of autophagy by the mammalian target of rapamycin (mTOR) inhibitor triggers PML/RARA destabilization in the NB4 APL cell line, resulting in enhanced ATRA-induced differentiation. Conversely, the autophagy inhibitor BafA impedes treatment-induced PML/ RARA degradation and biologic response. These results are important in...
Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17) translocation is a well-recognized complication of cancer treatment with agents targeting topoisomerase II. However, cases are emerging after mitoxantrone therapy for multiple sclerosis (MS). Analysis of 12 cases of mitoxantrone-related t-APL in MS patients revealed an altered distribution of chromosome 15 breakpoints versus de ...
Acute promyelocytic leukemia (APL) is always associated with chromosomal translocations that disrupt the retinoic acid receptor a (RARa) gene. Whether these translocations relate to a role for endogenous RARa in normal granulopoiesis remains uncertain because most studies addressing this question have used nonphysiological overexpression systems. Granulocyte differentiation in cells derived fro...
Acute promyelocytic leukemia (APL) is a subtype acutemyeloid leukemia inwhich leukemic promyelocytes predominate in the bone marrow (BM). Rapid diagnosis is critical for treatment decision since all-trans-retinoic acid must be administrated promptly. The microgranular variant may be of difficult diagnosis, as it may be confused with other diseases on morphological grounds. The purpose of this s...
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromo-somal translocations in acute promyelocytic leukemia TO THE EDITOR: We read an interesting paper by Palta et al. in a recent issue of the Korean Journal of Hematology tit...
In this issue, both Dong and Tweardy (page 2637) and Maurer et al (page 2647) offer a detailed functional and biochemical characterization of the Stat5b-RARa fusion protein, which was originally described in a patient with acute promyelocytic leukemia (APL) several years ago (Arnould et al, Hum Mol Genetics. 1999;8:1741-1749). Stat5b is one of 5 genes that have now been identified as fusion par...
Acute Promyelocytic Leukemia (APL) is one of the most curable leukemia which shows great sensitivity to all-trans retinoic acid (ATRA) although a small number of the patients present poor prognosis and short survival. Isochromosome 17 in APL which usually bears an additional copy of RARA/PML fusion gene is considered to be a negative factor on its prognosis. Cryptic t(15;17) on i(17q) leads to ...
Isochromosome of the long arm of the derivative chromosome 17, originating from the translocation t(15;17) [ider(17)(q10)t(15;17) or ider(17q)] in acute promyelocytic leukemia (APL), is a rare chromosome aberration which has been associated with a poor prognosis. In the present study, we report on 4 male APL patients with ider(17q) and review the clinical, cytogenetic and molecular characterist...
Typical acute promyelocytic leukemia (APL) is associated with expression of the PML-RARa fusion protein and responsiveness to treatment with all-trans retinoic acid (ATRA). A rare, but recurrent, APL has been described that does not respond to ATRA treatment and is associated with a variant chromosomal translocation and expression of the PLZFRARa fusion protein. Both PMLand PLZF-RARa possess id...
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