Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder with laboratory findings similar to those of congenital von Willebrand disease. We herein report a case of AVWS associated with Hashimoto's thyroiditis and subcutaneous mucosa-associated lymphoid tissue lymphoma. An IgG autoantibody against von Willebrand factor (VWF) was detected. The antibody bound to VWF but did not inhibit ...

Dear Editor, Acquired Factor VIII (FVIII) deficiency is a rare disorder occurring at a rate of approximately 1 person per million each year.1 It is due to the spontaneous development of auto-antibodies against FVIII. In 50% of the cases, no cause is identified, although it can be associated with pregnancy, autoimmune disease and malignancy.1 Inhibition of FVIII occurs and patients may present w...

A cquired von Willebrand’s disease (vWD) is a rare bleeding disorder with clinical and laboratory features mimicking the congenital form of the disease. An abnormal bleeding time, decreased levels of both factor VIII and von Willebrand factor (vWF), and moderate to severe mucosal bleeding characterize both forms of the disease. Acquired vWD occurs sporadically with no family history of vWD and ...

In women, von Willebrand disease (VWD) is the most common inherited bleeding disorder. Since VWD and other inherited bleeding disorders are autosomal disorders, they affect women and men. Menorrhagia, or heavy menstrual bleeding (HMB), is the most common symptom of women with bleeding disorder experience. Objectively, it is defined as bleeding that lasts for more than seven days or results in t...

Combined factor V and factor VIII deficiency (F5F8D) is a rare, autosomal recessive congenital bleeding disorder with a prevalence of 1:1,000,000. Individuals present with a variable clinical bleeding phenotype, elevated prothrombin time (PT) and partial thromboplastin time (PTT), and plasma levels of factor V and VIII of 5–30%. Mutations in 2 proteins, LMAN1 and MCFD, required for concurrent t...

astrointestinal bleeding from the biliary tree (hemobilia) s an uncommon event. Iatrogenic or traumatic liver injury re the most frequent causes of the disorder, accounting for ver 50% of cases, followed by gallstones, acalculous inflamation, vascular abnormalities and neoplastic disease [1]. are cases of spontaneous intracholecystic bleeding have een published in patients with vascular and coa...

Adults with bleeding disorders may present to their family physician with minor bleeding symptoms or hematologic laboratory abnormalities discovered during evaluation for surgery or another purpose. Identifying the small proportion of adults who have an underlying bleeding disorder as the cause for such signs or symptoms may be challenging. In cases of asymptomatic hematologic laboratory abnorm...

INTRODUCTION Afibrinogenemia is a rare coagulation disorder. Clinical features of spontaneous bleeding, bleeding after minor trauma, or after surgery have been described as well as thrombo-embolic complications. In this article, we presented the case of a 19-year old female with congenital afibrinogenemia who was admitted with a spontaneous intrahepatic hematoma. CONCLUSIONS Supportive treatm...

Acquired hemophilia is a rare disorder associated with serious bleeding in nonhemophilic patients. We had a 40-year-old woman who was diagnosed as acquired hemophilia with a factor VIII inhibitor level of 27.5 BU/mL. She was presented with gross hematuria and severe right shoulder pain, and was successfully treated with daily oral cyclophosphamide and prednisone for 2 weeks. After the remission...