under prolonged diabetic conditions, hba1c is produced from normal hemoglobin (hba0) through a non-enzymatic glycosylation or glycation, a process which enhances the hemoglobin susceptibility to be auto-oxidized to methemoglobin (methb). here we are reporting that the non-enzymatic reaction between fructose and methb (methb fructation) induces significant changes in the globin structure and deg...

Introduction Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generated during normal physiological processes are highly reactive with cellular lipids, DNA, and proteins. Superoxide and nitric oxide are the primary ROS and RNS, respectively, produced in cells, and both species react with other molecules and each other to form a diverse array of additional ROS and RNS (e.g., hyd...

Introduction Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generated during normal physiological processes are highly reactive with cellular lipids, DNA, and proteins. Superoxide and nitric oxide are the primary ROS and RNS, respectively, produced in cells, and both species react with other molecules and each other to form a diverse array of additional ROS and RNS (e.g., hyd...

We expose methods for in vivo assessment of oxygen, nitric oxide (NO), and reactive oxygen species (ROS)/reactive nitrogen species (RNS), in the microcirculation during normoxia and hypoxia. We provide an example of the related mechanisms of ROS/RNS and oxygen level in the process of regulating capillary perfusion. Namely, we discuss the real time pO(2) measurements in vivo in the microvessels ...

Oxidative stress Oxidative stress can be defined as an imbalance between the production of reactive oxygen species (ROS) in the body that disrupts its ability to detoxify reactive intermediates, or to repair the damage to organ and cellular systems that can be caused by ROS. Intracellular redox balance (the dynamic balance between oxidizing and reducing species within cells) is closely coupled ...

reactive oxygen species cause to release of dormancy in many plants such as sunflower seeds. this study investigated in order to evaluation role of reactive oxygen species germination and lipid proxidation in sunflower seeds. this study was performed in two separate experiments, each in a completely randomized design with factorial design with four replications.  in both experiments, uses from ...

background: excess reactive oxygen species (ros) in the semen is believed to affect fertility in men. morphologically abnormal sperms and their relation to seminal oxidative stress in infertile and subfertile men are not clear. objective: to correlate various sperm morphological defects with seminal oxidative stress in infertile and subfertile men. materials and methods: the study included 25 p...

to find the protective role of exogenous nitric oxide (no) on salinity-stressed rice seedlings, a crd-based factorial experiment with three replications was conducted in agronomy laboratory of the faculty of agricultural sciences, university of guilan, in 2012. the experimental design consisted of healthy and vigorous seedlings of two rice cultivars, khazar and goohar, the last already known as...