BACKGROUND Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications. OBJECTIVE/METHOD Here we give an overview of the most r...

OBJECTIVE To look for a relationship between the maternal age-specific incidence of complete molar pregnancy and the age-specific mid-follicular levels of circulating follicle stimulating hormone and luteinizing hormone. DESIGN Calculation of correlation coefficients between the incidence of complete mole and the circulating levels of follicle stimulating hormone and luteinizing hormone using...

BACKGROUND Gonadotropin cell is the main responsible for the secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), and immunocastration reduces the concentrations of serum FSH and LH. A few studies have reported the histological structure of gonadotropin cells obtained from immunocastration animals at the light microscopy level. However, the ultrastructure of gonadotropi...

OBJECTIVE To assess the single-dose pharmacokinetics of a recombinant human LH preparation administered by the i.v., i.m., and s.c. route. DESIGN Prospective, randomized cross-over study. SETTING Phase I clinical research environment. PATIENT(S) Twelve healthy pituitary down-regulated females. INTERVENTION(S) Subjects received single i.v., i.m., and s.c. doses of 10,000 IU of recombinan...

BACKGROUND Our objective was to investigate luteinizing hormone, follicle-stimulating hormone, testosterone, and androstenedione as predicitve markers for ovulation after laparoscopic ovarian drilling. METHODS We retrospectively analyzed 100 clompihen-resistant patients with the polycystic ovary syndrome who underwent laparoscopic ovarian drilling at our department. The main outcome measure w...