Spontaneous abortion (SAB) is defined as the expulsion of a fetus before 20 weeks of gestation or weighing less than 500 g.’ Losses after 20 weeks are described as stillbirths or premature births and, generally, have different etiologies than losses earlier in gestation. The vast majority of SABs occur before 12 weeks of gestation. Those occurring at less than 8 weeks often do not contain an em...

UNLABELLED Human reproduction is not considered a highly efficient biological process. Before the end of the first trimester, 30%-50% of conceptions end in spontaneous abortion. Most losses occur at the time of implantation. 15%-20% of clinical pregnancies end in spontaneous abortions. Recurrent pregnancy loss is a frustrating clinical problem both for clinicians and patients. Recurrent pregnan...

In recent decades, the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL) has been studied extensively. Although the first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication s...