This paper investigates a technique for developing investment assumptions for pricing that are consistent with the investment practices of the company. An investment strategy is defined to be a specific allocation of investable funds among given representative fixed-income instruments. The investment strategy problem consists of two parts: how to invest funds initially received on a block of ne...

The comparison of alternative treatments has long been a primary objective of researchers engaged in clinical investigation. However, with the commitment of $1.1 billion in support of clinical research in the American Recovery and Reinvestment Act,1 followed subsequently by the creation of the Patient Centered Outcomes Research Institute (PCORI) as part of the Affordable Care Act,2 “comparative...