1.1 Macular degeneration: clinical aspects Age-related macular degeneration (AMD) is the leading cause of irreversible blindness. (Klaver, et al 1998, Klein 2007). The disease adversely affects quality of life and activities of daily living, causing many affected individuals to lose their independence in their retirement years. It is estimated that, in the USA, over 8 million people have some s...

1. Doyle SL, campbell M, Ozaki E, et al. NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat. Med. 2012; 18: 791– 798. 2. tarallo V, Hirano Y, Gelfand BD, et al. DIcER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. cell 2012; 149: 847–859. 3. Kauppinen A, Niskanen H, Suuronen t,...

Abstract Background Visual acuity is commonly used as a functional outcome measure in patients with age-related macular degeneration (AMD), despite having weak correlation self-perceived visual quality of life. Microperimetry useful method detecting loss function. We wanted to investigate the relationship between these two objective measures and subjective vision-related life, finding out which...

Oxidative stress due to free radicals is involved in the pathogenesis of many chronic disorders including cancer, inflammation and neurological diseases. Reactive oxygen species (ROS) may be implicated in age-related macular degeneration (AMD).This study investigated the expression of manganese superoxide dismutase MnSOD on mRNA and protein level. Moreover it examines the genetic sequence polym...

Age-related macular degeneration (AMD) is an ocular disease that causes damage to the retinal macula, mostly in the elderly. Normal aging processes can lead to structural and blood flow changes that can predispose patients to AMD, although advanced age does not inevitably cause AMD. In this review, we describe changes that occur in the macular structure, such as the retinal pigment epithelium a...

Macular degeneration is one of the most common retinal diseases in India. Usually it is observed in people over 60s and is therefore called age related Macular degeneration, ARMD or AMD. The macula is responsible for the sharp central vision needed for detailed activities such as reading, writing, driving, face recognition and ability to see colours. Age related macula degeneration is degenerat...

Macular degeneration is one of the most common retinal diseases in India. Usually it is observed in people over 60s and is therefore called age related Macular degeneration, ARMD or AMD. The macula is responsible for the sharp central vision needed for detailed activities such as reading, writing, driving, face recognition and ability to see colours. Age related macula degeneration is degenerat...

Macular degeneration is one of the most common retinal diseases in India. Usually it is observed in people over 60s and is therefore called age related Macular degeneration, ARMD or AMD. The macula is responsible for the sharp central vision needed for detailed activities such as reading, writing, driving, face recognition and ability to see colours. Age related macula degeneration is degenerat...