UNLABELLED Leishmaniasis has been documented in several countries, with an estimated prevalence of 12 million people and an incidence at around 400,000 new cases per year. Leishmaniasis in the New World is one the major endemic diseases in Brazil and Latin America. OBJECTIVE The aim of this study was to add to the current knowledge on mucosal leishmaniasis, bringing the experience of the Immu...

lichen planus is a chronic inflammatory mucocutaneous disease. mucosal lesions are classified into six clinical forms and there is malignant potential for two forms of olp; therefore, follow-up should be considered. there are many un-established etiological factors for olp and some different treatment modalities are based on etiology. the aims of current olp therapy are to eliminate mucosal ery...

The plasticity region of Helicobacter pylori is a large chromosomal segment including isolate-specific open reading frames with characteristics of pathogenicity islands. It remains unclear whether genes in the plasticity region play a role in the pathogenesis of gastric mucosal inflammation and gastroduodenal disease. Our aim was to assess the role of selected genes in the plasticity region in ...

background: it is important to understand the efficacy of immunoregulatory materials, herbal remedies or probiotics, in different parts of immune system following vaccination with different tropism. objectives: aim of this study was to evaluate the effect of echinacea purpurea and a probiotic (protexin) on systemic and mucosal immune response in turkey. methods: a total of 288 1-day-old male tu...

Background and Objective: Diagnosis of Hirschsprung’s disease (HD) as the most common cause of neonatal intestinal obstruction is based on the presence of aganglionosis from seromuscular or full thickness biopsy. Due to the complication of full thickness or seromuscular rectal biopsy, mucosal-sub mucosal...

BACKGROUND Health-related quality of life [HRQoL] is impaired in ulcerative colitis and is correlated to clinical disease activity. The recent shift towards more objective treatment goals like mucosal healing generates a need for evaluating the association between endoscopic disease activity, mucosal healing and HRQoL. METHODS In this cross-sectional study, patients with either active or inac...

Oral lichen planus is a chronic non-infectious mucosal inflammatory disease caused by an imbalance between reactive oxygen species homeostasis and antioxidant defense systems. Notably, excessive oxidative stress products result in related autoimmune reactions. Further, it activates signaling pathways to the development of oral planus, as evidenced detection damage deoxyribonucleic acid, protein...

Abstract Background Alcohol-related liver disease (ALD) is a major cause of chronic diseases. Inflammatory response basic pathological feature ALD. Mucosal-associated invariant T(MAIT) cells are novel population innate immune cells, which may be depleted in various inflammatory However, the changes MAIT cell ALD remains unclear. Results In this study, levels were significantly decreased patient...