The authors explore likelihood-based methods for making inferences about the components of variance in a general normal mixed linear model. In particular, they use local asymptotic approximations to construct confidence intervals for the components of variance when the components are close to the boundary of the parameter space. In the process, they explore the question of how to profile the re...

The widespread use of the set of multiple-trait derivative-free REML programs for prediction of breeding values and estimation of variance components has led to significant improvement in traits of economic importance. The initial version of this software package, however, was generally limited to pedigree-based relationships. With continued advances in genomic research and the increased availa...

In order to ascertain changes in bitterness as beer aged naturally, time±intensity (TI) measurements were made by a professional sensory panel using a squeezer transducer system. TI parameters were ®tted by variance components models using Restricted Maximum Likelihood (REML). It was shown that bitterness decreased with age, although this age-induced di€erence was smaller than the original di€e...

Six packages for solving mixed model equations and estimating variance components by REML are compared. Each has a unique strength. Meticulously finished DFREML is the only one that implements hypothesis testing for variance component estimates. MTDFREML is a comprehensive, relatively easy to install and simple to use package for analyses of experimental data. PEST, the only semi-commercial pro...

INTRODUCTION Random regression (RR) models for longitudinal data often require a considerable number of parameters to describe the associated covariance functions. Estimation of these parameters has proven cumbersome and subject to sampling problems. Moreover, computational restraints have limited analyses of data sets sufficiently large to supply accurate estimates. This holds especially for c...

Fluoxetine and placebo were compared in 89 outpatients with major depression with (n = 45) or without (n = 44) a reduced or shortened rapid eye movement latency (SREML) (< or = 65 minutes) to determine whether rapid eye movement latency (REML) predicted placebo and/or antidepressant response. Men and women were stratified based on polysomnographic recordings and then randomly assigned to receiv...

In order to estimate genetic parameters for production traits and reproductive performance, 115 465 records of production traits and 90 942 records of reproductive performance from Iranian Holstein cows that were collected during 1980 to 2004 at Animal Breeding Center of Iran, were used. The estimations were performed using Restricted Maximum Likelihood method (REML) under an animal model by DF...

In a recent paper published in PNAS (Golan et al. 2014), residual maximum likelihood (REML) seriously underestimated genetic variance explained by genomewide single nucleotide polymorphism when using a case-control design. It was concluded that Haseman–Elston regression (denoted as PCGC in their paper) should be used instead of REML. Their conclusions were based on results from simplified linka...