Introduction: This study investigated the effect of berberine on renal dysfunction and histological damages of the lung induced by renal ischemia/ reperfusion at an early stage. Methods: There were four experimental groups of adult male rats (n=7). Seven days before induction of ischemia, the Ber+I/R group received oral (by gavage) berberine (15 mg/kg/day) while the I/R group received distil...

This brief review discusses some aspects of hypertensive damage to the kidneys and cardiovascular system. A comparison of renal and cardiac manifestations of hypertensive disease between results of clinical and experimental studies was made, with a major focus on the possible role of salt and the renin-angiotensin system (RAS) in inducing target organ damage. Thus, some degree of renal impairme...

Damage to the kidneys is one of the primary toxic actions of metals. Nephrotoxic substances not only cause renal disease directly, but they can also destroy renal reserve capacity, potentially placing those people with additional risk factors, such as diabetes, hypertension, cardiovascular disease, and genetic predispositions, at greater risk. To detect nephrotoxicity in people at a stage where...

OBJECTIVE To study the effect of renal disease on the standardized mortality ratio (SMR) and life expectancy of patients with systemic lupus erythematosus (SLE). METHODS Patients whose diagnosis met ≥4 American College of Rheumatology criteria for SLE were longitudinally followed up from 1995 to 2011. The cumulative survival rate, SMR, and life expectancy were calculated, and the effect of re...

1 Department of Emergency and Organ Transplantation, Urology, Andrology and Kidney Transplantation Unit, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy 2 Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC Leiden, The Netherlands 3 Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of ...

Introduction The natural history of acute tubular necrosis in adults has been well documented, but accounts of the condition in infants and children are rare. Most of the descriptions of tubular necrosis in the paediatric literature refer to older children (Riddell, 1951; Kaplan and Fomon, 1953; Wagner, 1954), but Pratt (1948) described two cases due to sulphonamides, aged 10 months and 18 mont...

background: it has been shown that serum total homocysteine (hc) is a risk factor for vascular disease which characterizes endothelial damage in the general and in the end-stage renal disease (esrd) population as well. whether n-3 polyunsaturated fatty acids decrease homocysteine (hcy) level has been a subject of controversy. methods: renal transplant patients were randomized in 2 groups and re...

Endothelial dysfunction (ED) seems to be a crucial mediator of increased cardiovascular risk observed among patients with chronic kidney disease (CKD). Importantly, systemic ED does not only occur in patients with severe renal failure, but also in individuals with earlier stages of CKD. Close association between microalbuminuria and systemic ED renders renal vascular function an important marke...