Group B coxsackieviruses can initiate rapid onset type 1 diabetes (T1D) in old nonobese diabetic (NOD) mice. Inoculating high doses of poorly pathogenic CVB3/GA per mouse initiated rapid onset T1D. Viral protein was detectable in islets shortly after inoculation in association with beta cells as well as other primary islet cell types. The virulent strain CVB3/28 replicated to higher titers more...

Replication is a technique which is widely used for speeding up access to passive objects. Consistency requirements of distributed object oriented programming languages, however, limit the scope of object replication to coarse grain objects or objects which are modiied infrequently. This is due to the fact that the overhead for global synchronization and preserving replica consistency often out...

Subrota K. Mondal 1,*, Jogesh K. Muppala 1,* and Fumio Machida 2 1 Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China 2 Laboratory for Analysis of System Dependability, Kawasaki 210-0832, Japan; [email protected] * Correspondence: [email protected] (S.K.M.); [email protected] (J.K.M.); Tel.: +852-23...

DNA replication in eukaryotes initiates at specific sites known as origins of replication, or replicators. These replication origins occur throughout the genome, though the propensity of their occurrence depends on the type of organism. In eukaryotes, zones of initiation of replication spanning from about 100 to 50,000 base pairs have been reported. The characteristics of eukaryotic replication...

Fault Tolerance must be provided to increase system reliability. Combining efficiency with fault tolerance is a difficult task. Fault Tolerance requires the use of redundancy while efficiency requires the elimination of redundancy. Several fault tolerance techniques have been proposed in the literature to manage the redundancy existing in the system in order to provide fault tolerance. These te...

Viruses hijack host factors for their high speed protein synthesis, but information about these factors is largely unknown. In searching for genes that are involved in viral replication, we carried out a forward genetic screen for Drosophila mutants that are more resistant or sensitive to Drosophila C virus (DCV) infection-caused death, and found a virus-resistant line in which the expression o...

In this paper, we study the safety guarantees of group communicationbased database replication techniques. We show that there is a model mismatch between group communication and database, and because of this, classical group communication systems cannot be used to build 2-safe database replication. We propose a new group communication primitive called end-to-end atomic broadcast that solves the...

In this paper, we present a new parallel EM algorithm with the optimal data replication on a hypercube niultiprocessor. Although data replication has been frequently used to reduce data sharing overhead, none of the parallel EM algorithms have attempted to optimize the data replication. To maximize efficiency of the proposed parallel EM algorithm, data replication have been optimized through st...

We constructed a nondefective retrovirus vector based on spleen necrosis virus (SNV), a replication-competent reticuloendotheliosis virus. We introduced different DNA sequences into this vector and studied the ability of the resulting viruses to replicate in chicken embryo fibroblasts. The replication efficiency of SNV-derived viruses decreased with increasing virus size. Viruses larger than 9....

We have studied the in vivo replication properties of plasmids carrying deletion mutations within cloned adenovirus terminal sequences. Deletion mapping located the adenovirus DNA replication origin entirely within the first 67 bp of the adenovirus inverted terminal repeat. This region could be further subdivided into two functional domains: a minimal replication origin and an adjacent auxillar...