BACKGROUND Eukaryotic cells seem unable to monitor replication completion during normal S phase, yet must ensure a reliable replication completion time. This is an acute problem in early Xenopus embryos since DNA replication origins are located and activated stochastically, leading to the random completion problem. DNA combing, kinetic modelling and other studies using Xenopus egg extracts have...

In this paper, we prove effective estimates for the number of exceptional values and the totally ramified value number for the Gauss map of pseudo-algebraic minimal surfaces in Euclidean four-space and give a kind of unicity theorem.

This paperdescribes awayof organizing information about an object-orientedprogram’s execution. The context is our system for visualizing that execution. The critical constraints are completeness, compactness, and efficient retrieval. We describe our design and how it meets these constraints.

SRC kinases and PKR are intracellular protein kinases, which play key roles in intracellular viral replication. In this research, the effect of SRC kinase inhibition and PKR activation and inhibition on replication of coxsakievirus (CVB3), an entrovirus of the family picornaviridae – causative agents of fatal myocarditis, was studied. Vero and Hela cells were cultured and infected with CVB3 in ...

This report examines the molecular mechanism by which high-fidelity DNA polymerases select nucleotides during the replication of an abasic site, a non-instructional DNA lesion. This was accomplished by synthesizing several unique 5-substituted indolyl 2'-deoxyribose triphosphates and defining their kinetic parameters for incorporation opposite an abasic site to interrogate the contributions of ...

objective: in this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. dna topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as dna replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the dna. result...

abstract— data grids are an important branch of gird computing which provide mechanisms for the management of large volumes of distributed data. energy efficiency has recently emerged as a hot topic in large distributed systems. the development of computing systems is traditionally focused on performance improvements driven by the demand of client's applications in scientific and business ...

In this note we study a minimization problem for a vector of measures subject to a prescribed interaction matrix in the presence of external potentials. The conductors are allowed to have zero distance from each other but the external potentials satisfy a growth condition near the common points. We then specialize the setting to a specific problem on the real line which arises in the study of c...