The genetic risk landscapes of adult and paediatric cancers are quantitatively qualitatively different. Adult cancer is a common but sporadic phenomenon: fewer than 10% patients carry allele, predominantly in genes involved DNA maintenance. In contrast, rare disease which germline alleles observed at higher frequency broader set genes, including regulators signalling development. Beyond these g...

We had attempted to publish a report of an unusual manifestation of an uncommon disease discovered at autopsy. The case report was not accepted for publication because we had failed to order a highly specific test that would have unequivocally confirmed the diagnosis we entertained and subsequently wrote about. After much deliberation about this case and an extensive review of the literature, w...

Light-chain amyloidosis (AL-CA) and transthyretin (ATTR-CA) are the most common types of cardiac (CA). We sought to study clinical characteristics prognosis both diseases. conducted a single-centre, retrospective review all patients diagnosed with CA between 1998 2018. Clinical characteristics, complementary tests, survival other adverse events were studied. identified 105 CA, 65 ATTR-CA 40 AL-...

Background: Ectopic pregnancy (EP) is a common condition which presents a major health problem for women of childbearing age. This study aims to analyze and identify risk factors that have the potential for EP and evaluating the contribution of the risk factors associated EP. Materials and Methods: In this case control study, performed from 2006 to 2011 at Arash hospital, the casepatients were ...