psychological disorders such as depression have more prevalence in inflammatory bowel disease patients and can exacerbate the clinical course of the disease, so anti-depressant therapy may have a potential to positively impact the disease course. on the other hand several antidepressant drugs have shown anti-inflammatory and immunomodulatory properties. thus, this study aimed to explore the ben...

1. A progressive but incomplete adaptation of the aortic baroreceptor was observed after 1 and 6 h of hypotension in rats subjected to controlled bleeding. Administration of phenoxybenzamine produced a greater downward displacement of baroreceptor activation range. 2. Complete adaptation was observed after 48 h of maintained hypotension in rats treated with reserpine. 3. The range of the aortic...

樽 口 秀雄 ・松尾 高明 ・中谷〓 二 ・島本 暉朗 One of the side actions which restrict the clinical use of reserpine is a strong and long-lasting mental depression. Looking for other reserpine-like alkaloids less toxic and more useful for clinical trials than reserpine, Velluz et al. (1, 2) have presented 10 methoxydeserpidine (decaserpine), an isomer of reserpine . The pharmacological effects of decaserpine have ...

AIMS We investigated the role of endothelin-B receptors on sympathetic activation originating from the adrenal gland or from the myocardium and its impact on arrhythmogenesis during acute myocardial infarction. MAIN METHODS We studied two groups of rats (n=120, 284±2 g), namely wild-type and ETB-deficient. Myocardial infarction was induced by permanent ligation of the left coronary artery and...

m [Ib assess the eencacy of difTerent period of treatment fbr evaluating male reproductive toxicity in rats, reserpine was subcutaneously administered on a daily basis to male Sprague-Dawley rats at dosages of O.05, O.1 or O.2 mgfkg for 2 weeks or at dosages of O,05 or O, 1 mglkg fbr 4 weeks. At the end of the administration period the animals were sacrificed and sperm counts, organ weights and...

Adrenomedullary cells, after fixation with OsO(4), are filled with well formed granules which are considered to represent their catechol amine content. The submicroscopic appearance of these cells was studied in reserpine-treated rats during the late phase of catechol amine depletion and during the period of its restoration. At 3 days after the beginning of reserpine treatment, the granules app...

The tyrosine-3-monooxygenase activity [L-tyrosine, tetrahydropteridine: oxygen oxidoreductase (3-hydroxylating); EC 1.14.16.2] of rat adrenal medulla is induced 20-24 hr after the injection of reserpine (16 mumol/kg intraperitoneally). This and other inducing stimuli increase the 3': 5'-cyclic AMP (cAMP) content in the medulla for longer than 60 min and activate the cAMP-dependent protein kinas...

The pain-depression dyad is becoming widespread in the clinic and is attracting increasing attention. A previous study by our group found that 100-Hz electro-acupuncture (EA), but not 2-, 50- and 2/100-Hz EA, was effective against the reserpine-induced pain-depression dyad. This finding is in contrast to the fact that low-frequency EA is commonly used to treat supraspinal-originating diseases. ...

Autonomic dysfunctions play important roles in hypertension, heart failure and arrhythmia, often with a detrimental and fatal effect. The present study analyzed if these dysfunctions involved M-channels (members of the Kv7/KNCQ family) in spontaneously hypertensive rats (SHR). Cardiac output and heart rate (HR) were recorded by a flow probe on the ascending aorta in anesthetized SHR and normote...

The mechanism of ovulation in mammalians has been brought to the field of study in the past decade. The ovulation is undoubtedly induced by the gonadotropin from the adenohypophysis. On the other hand the mechanism controlling the release of gonadotropin from the adenohypophysis has not been clearly elucidated. No matter what mechanism is involved in triggering the gonadotropin secretion from a...