Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that express GABA. However, little is known about how sleep neuron function is determined and how sleep neurons change physiology and behavior systemically. Here, we investigated sleep in Caenorhabditis elegans, which is induced by the single sleep-active neuron RIS. We found that the transcription factor LI...

[1] The relationship between small-magnitude seismicity and large-scale crustal faulting along the Hayward Fault, California, is investigated using a double-difference (DD) earthquake location algorithm. We used the DD method to determine high-resolution hypocenter locations of the seismicity that occurred between 1967 and 1998. The DD technique incorporates catalog travel time data and relativ...

There has been a significant increase in earthquakes in Central and Eastern US (CEUS) in recent years. This increase in seismicity has been associated with human activities like wastewater injection, and is referred to as induced seismicity. One of the components for hazard and risk calculation from induced seismicity is the level of ground shaking expected from an earthquake at a site of inter...

Abstract The utilisation of geothermal energy in the Netherlands is primarily focused on deep sedimentary aquifers, which are often intersected by major faults. Geothermal operations (i.e. fluid production and injection) may alter effective stress state along these faults trigger induced seismic events. Pore pressure perturbations have been generally considered main driver injection-induced sei...

Fluid injection into deep wellbores can increase pore pressure, reduce effective stress, and trigger earthquakes. The extent of the seismogenic response to injection provides insight into how close faults are to failure in the injection-affected area. The seismogenic response to injection operations in hydrocarbon basins is examined in California and Oklahoma. Changes in spatial and temporal se...

In this research, we use high frequency waveform information to determine the focal mechanisms of small local earthquakes at an oil reservoir. During the waveform inversion, we maximize both the phase and amplitude matching between the observed and synthetic waveforms. In addition, we use the polarities of the first P-wave arrivals and the S/P amplitude ratios to better constrain the matching b...

BACKGROUND: Radiation therapy (XRT) is an important modality in the treatment of cancer, and XRT is now commonly utilized in the treatment of early-stage breast cancer. However, its use has occasionally resulted in the development of secondary malignancies. We present a critical review of radiation-induced sarcoma (RIS) that develops after irradiation for the treatment of breast cancer. METHODS...

Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antagonist, whereas most APs in current clinical use interact with multiple neurotra...