We aimed to estimate the prevalence of resistant hypertension through both office and ambulatory blood pressure monitoring in a large cohort of treated hypertensive patients from the Spanish Ambulatory Blood Pressure Monitoring Registry. In addition, we also compared clinical features of patients with true or white-coat-resistant hypertension. In December 2009, we identified 68 045 treated pati...

The aim of this study was to evaluate whether sustained hypertensives with high clinic blood pressure, despite multiple drug treatment, show a true resistant hypertension or a ‘‘white-coat effect,’’ and whether the pretreatment white-coat effect is maintained despite pharmacological therapy. The occurrence of resistant hypertension was determined in 250 consecutive essential hypertensives who h...

Hypertension is a major risk factor for cardiovascular disease, resulting in increased incidence of cerebrovascular events, ischaemic heart disease, heart failure, and renal impairment. Thus, it is one of the most important preventable causes of premature morbidity and mortality. Despite current knowledge on the management of hypertension and the availability of several effective antihypertensi...

1. Rats genetically sensitive to salt-induced hypertension showed higher levels of plasma noradrenaline and adrenaline than rats genetically resistant to hypertension. 2. The hypertension-sensitive rats had higher hypothalamic noradrenaline and lower adrenaline than resistant rats. 3. In response to a high salt diet brain-stem noradrenaline increased in sensitive rats and resistant rats exhibit...

The term “resistant hypertension” (RH) evokes a myriad of clinical descriptions, nearly all of which implicitly ascribe origins of the problem to characteristics inherent within the patient or maleficent qualities of the disease itself. The need for an operational definition to help identify and prioritize a higher-than-average-risk population that could benefit from special diagnostic and ther...

BACKGROUND Obstructive sleep apnea syndrome (OSAS) has been linked to resistant hypertension, but the magnitude of this association and its independence of confounding have not been established. METHODS Case patients were 63 patients with resistant hypertension (BP >or= 140/90 mm Hg using at least three BP-lowering drugs, including a diuretic), and control subjects were 63 patients with contr...

Resistance of hypertensive patients to large doses of guanethidine is seldom due to defective absorption of the drug, since the existence of adrenergic blockade can be demonstrated in these cases. The effect on the blood pressure of intravenous phenoxybenzamine and norepinephrine, respectively, has been compared in groups of hypertensive patients resistant and responsive to guanethidine. As bot...