Despite much progress, few genetic findings for schizophrenia have been assessed by functional validation experiments at the molecular level. We previously reported evidence for genetic linkage of broadly defined schizophrenia to chromosome 17q25 in a sample of 24 multiplex families. 2,002 SNPs under this linkage peak were analyzed for evidence of linkage disequilibrium using the posterior prob...

OBJECTIVE Due to limited resources, improvement of preservation solutions is still of great importance in cardiac transplant surgery. New additives with antioxidant properties were tested with respect to coronary function of isolated rat hearts. METHODS Bretschneider HTK solution containing none or an antioxidant additive (deferoxamine, trolox or LK 616) was used for 8h cold cardioplegia. Aft...

Functional peptides have been produced by proteolysis of glucoamylase (glucan 1,4-alpha-glucosidase; EC 3.2.1.3) from Aspergillus niger and purified by affinity chromatography, gel filtration and two ion-exchange-chromatography steps. The peptides correspond to residues 499-616 and 509-616 of the original glucoamylase molecule. Together with G1C (residues 471-616 from glucoamylase 1) [Belshaw &...

Yusook Chung, Tae-Joong Lim, Young Kwang Park, Jong Won Kim, Jung Hoan Cho, Chang Kwon, Hyun Yong Lee, Myung Jun and Sanghyun Lim. Journal of the Korean Society Food Science Nutrition 2023;52:616-27. https://doi.org/10.3746/jkfn.2023.52.6.616

Abstract Introduction The diagnosis and treatment of Gastro-intestinal stromal tumours (GISTs) has been revolutionized by molecular pathology targeted therapy. Description This patient was diagnosed with locally advanced gastric GIST in 2009. He initially treated neoadjuvantly imatinib from 2009- 2010. underwent laparoscopic resection Pathology showed almost complete response only 1.5mm focus v...

Abstract So-called respectively readings have posed serious challenges for theories of syntax and semantics. Sentences like George and Martha respectively denounced and were denounced by the governor (McCawley 1998) show that although the conjoined verbal expressions share the same syntactic subject, they do not predicate that subject in the same way; George (not Martha) denounced the governor,...

RecQ helicases have attracted considerable interest in recent years due to their role in the suppression of genome instability and human diseases. These atypical helicases exert their function by resolving a number of highly specific DNA structures. The crystal structure of a truncated catalytic core of the human RECQ1 helicase (RECQ1(49-616)) shows a prominent β-hairpin, with an aromatic resid...