The key feature of respiratory distress syndrome (RDS) is the insufficient production of surfactant in the lungs of preterm infants. As a result, researchers have looked into the possibility of surfactant replacement therapy as a means of preventing and treating RDS. We sought to identify the role of surfactant in the prevention and management of RDS, comparing the various types, doses, and mod...

Surfactant replacement therapy by ‘INSURE’ is a gentle ventilatory approach in preterms with Respiratory Distress Syndrome (RDS) reducing the mortality and is associated with less adverse sequelae than mechanical ventilation. The objective of the present study is to determine the role of surfactant therapy by INSURE in reducing the mortality of preterms with RDS. 59 preterm babies with RDS were...

Grover TR, Asikainen TM, Kinsella JP, Abman SH, White CW. Hypoxia-inducible factors HIF-1 and HIF-2 are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs. Am J Physiol Lung Cell Mol Physiol 292: L1345–L1351, 2007. First published February 16, 2007; doi:10.1152/ajplung.00372.2006.— Respiratory distress syndrome (RDS) secondary to preterm birth and surfac...

The purpose of this retrospective study was to investigate the neonatal outcome of preterm infants born to mothers with placenta previa (PP), especially the outcome of respiratory distress syndrome (RDS). The preterm infants born to PP mothers treated with expectant management and admitted to a tertiary care hospital between January 1989 and December 1995 were sequentially included. Obstetrical...

AIM To determine whether abnormal transvascular protein flux can be measured with positron emission tomography (PET) in neonates with respiratory distress syndrome (RDS). METHODS Fourteen infants with normal gas exchange (non-RDS group) underwent one PET measurement and 12 infants with RDS (the RDS group) underwent two measurements of protein flux, as determined by the pulmonary transcapillar...

BACKGROUND Adenosine triphosphate (ATP)-binding cassette transporter A3 (ABCA3) gene mutations cause fatal respiratory failure in term infants, but common ABCA3 polymorphisms have remained uncharacterized at the population level. AIM To define a subset of tagging single-nucleotide polymorphisms (tSNPs) which capture most of the variation within the ABCA3 gene, and to assess ABCA3 as a novel c...

despite improvement of mechanical ventilation devices for infants, lung injury still causes morbidity and mortality in many cases. to determine the effect of high frequency oscillatory ventilation (hfov) in infants with severe respiratory failure, 10 neonates were evaluated prospectively. mean gestational age of these patients was 35 weeks and alveolar-arterial oxygen gradient (a-ado2) and the ...

BACKGROUND Neonates with the diagnosis of respiratory distress syndrome (RDS) were studied to investigate possible associations between cytokine levels at birth and developing severe RDS or chronic lung disease (CLD). MATERIALS AND METHODS This was a cross-sectional study on serum and bronchoalveolar lavage (BAL) samples collected within hours of birth from infants with moderate and severe RD...