Respiratory syncytial virus (RSV) bronchiolitis is an important cause of severe respiratory disease in infants. This study aimed to characterise changes in pulmonary pro- and anti-inflammatory responses in infants with RSV bronchiolitis over the course of the illness. On the day of intubation (Day 1) and the day of extubation (Day X), nonbronchoscopic bronchoalveolar lavage was performed on ter...

Respiratory syncytial virus (RSV) bronchiolitis is the most common lower respiratory tract infection in infancy. To date, there is no effective therapy for RSV bronchiolitis. In order to investigate the efficacy of clarithromycin in the treatment of RSV bronchiolitis, the present authors conducted a randomised, double-blind, placebo-controlled trial comparing clarithromycin with placebo in 21 i...

To assess molecular evolution of the respiratory syncytial virus (RSV) fusion gene, we analyzed RSV-positive specimens from 123 children in Canada who did or did not receive RSV immunoprophylaxis (palivizumab) during 2006-2010. Resistance-conferring mutations within the palivizumab binding site occurred in 8.7% of palivizumab recipients and none of the nonrecipients.

GS-5806 is a small-molecule inhibitor of human respiratory syncytial virus fusion protein-mediated viral entry. During viral entry, the fusion protein undergoes major conformational changes, resulting in fusion of the viral envelope with the host cell membrane. This process is reproduced in vitro using a purified, truncated respiratory syncytial virus (RSV) fusion protein. GS-5806 blocked these...

Background.  Because the production of an effective respiratory syncytial virus (RSV) vaccine for infants is challenging, vaccination of other family members is one viable alternative to prevent severe RSV illnesses in infants. Methods.  In a prospective study, we enrolled all family members of children who were hospitalized with RSV infection. Nasal swabs for RSV detection were obtained from a...

Objective: To determine the frequency of respiratory syncytial virus (RSV) among hospitalized children with acute lower tract infections (ALRI) and associated risk factors.
 Study Design: Comparative cross-sectional study.
 Place Duration Study: Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jul 2019 to Aug 2020.
 Methodology: After approval Ethical Review Board, 126 w...

The seasons associated with laboratory isolation of respiratory syncytial virus (RSV) (for 1981-2004) and RSV-related emergency department admissions (for 1990-2004) ended 3.1 and 2.5 weeks earlier, respectively, per 1 degrees C increase in annual central England temperature (P=.002 and .043, respectively). Climate change may be shortening the RSV season.

Abstract One of the main cause of severe respiratory infection in infants and young children is respiratory syncytial virus (RSV). The disease can also occur in adults and elderly individuals and clinically not to be differentiated from other viral respiratory infection. The disease causes bronchiolitis, and sometimes pneumonia in new born and young children which requires hospital care. To di...

Respiratory syncytial virus (RSV) is an important cause of severe lower respiratory tract illness in infants and the elderly. Presently, no safe and efficacious RSV vaccine exists; however, advances in our understanding of immunity and the pathogenesis of disease associated with RSV infection may lead to new vaccine strategies. RSV G protein contains a CX3C chemokine motif that interacts with t...

Piedimonte, Giovanni, Maria M. Rodriguez, Katherine A. King, Stafford McLean, and Xiaobo Jiang. Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. Am. J. Physiol. 277 (Lung Cell. Mol. Physiol. 21): L831–L840, 1999.—Respiratory syncytial virus (RSV) is a major respiratory pathogen in infants. The first goal of this study was to determine whether the infe...