Fludarabine-containing combinations have additive cell killing against leukemic blasts in vitro. It has also been shown that imatinib mesylate combined with fludarabine or cladribine had an additive effect on CML CFU-GM cells. In this regard, we aimed to investigate the effect of fludarabine-imatinib mesylate combination against CML blastic phase cell lines K562 and Meg-01. XTT test was perform...

Propolis is a natural resinous substance collected by bees from tree exudates and secretions. Its antimicrobial activity has been investigated and inhibitory action on Staphylococcus aureus growth was evaluated. The in vitro synergism between ethanolic extract of propolis (EEP) and antimicrobial drugs by two susceptibility tests (Kirby and Bauer and E-Test) on 25 S. aureus strains was evaluated...

OBJECTIVE To study the synergism between neuropeptides and lithium ions. MATERIAL AND METHODS An experimental model of stroke (chronic bilateral occlusion of the common carotid arteries in rats), neuronal culture studies, histomorphological analyses, determination of micronutrient profile of brain substrates were used. RESULTS A complex of experimental studies revealed that the effect of ce...

the aim of this investigation was to assess the in vitro interaction of two antifungal agents, econazole-nitrate and chelerythrine, against ten fluconazole-resistant clinical isolates and one atcc type strain 10231 of candida albicans. the checkerboard microdilution method was performed according to the recommendations of the national committee for clinical laboratory standards, and the results...

objective(s): to evaluate the in vitro interaction between different extracts of thymbra spicata l. and certain antimicrobial drugs of different mechanisms, including ampicillin, cefotaxime, amikacin and ciprofloxacin. this study was performed against multidrug-resistant strains of staphylococcus aureus and klebsiella pneumoniae. materials and methods: evaluation of antibacterial activity and s...

In the real world, risk and uncertainty are two natural properties in the implementation of Mega projects. Most projects fail to achieve the pre-determined objectives due to uncertainty. A linear integer programming optimization model was used in this work to solve a problem in order to choose the most appropriate risk responses for the project risks. A mathematical model, in which work structu...

accelerating wound healing is now considered as a principle clinical treatment and increasing the quality and speed of healing which has always been emphasized by the scientists. propolis and honey are natural bee products with wide range of biological and medicinal properties. this study was aimed to determine the synergistic effect of honey and propolis in wound healing of rat skin. a total o...