Excessive blood vessel growth is a key feature of many retinal diseases, and recently, anti-VEGF therapy has been successfully applied to treat neovascular age-related macular degeneration (AMD), diabetic macular edema, and retinal vein occlusion. In this issue of the JCI, Kurihara et al. reveal an essential role of Vegfa in maintaining choroid vasculature and cone photoreceptors, critical for ...

Blood vessel segmentation is important for the analysis of ocular fundus images for diseases affecting vessel caliber, occlusion, leakage, inflammation, and proliferation. We introduce a novel supervised method to evaluate performance of Leung-Malik filters in delineating vessels. First, feature vectors are extracted for every pixel with respect to the response of Leung-Malik filters on green c...

purpose: to assess the effectiveness of intravitreal injection of triamcinolone acetonide on macular edema associated with branch retinal vein occlusion (brvo). design: a prospective noncomparative interventional case series. patients & methods: fourteen eyes of 14 patients with macular edema associated with brvo were enrolled. in all patients after thorough ophthalmic examination, 4 mg triamci...

We report a case of transient reduction in the diameter and tortuosity of an occluded vessel after intravitreal administration of 1.25 mg (0.05 ml) bevacizumab in a patient with ischaemic branch retinal vein occlusion. A 64-year-old hypertensive female presented with chief complaints of reduced vision in her right eye for 3 months. Her vision in the right eye was evaluated as counting fingers a...

Retinal vein occlusion is one of the vascular disorders affecting vision. Branch retinal vein occlusion and central retinal vein occlusion are the two basic types of vein occlusion. Branch retinal vein occlusion is three times more common than central retinal vein occlusion and is second only to diabetic retinopathy as the most common retinal vascular cause of visual impairment. The origin of b...

purpose : to evaluate the effectiveness of intravitreal triamcinolone acetonide on visual acuity and macular thickness using optical coherence tomography in macular edema associated with nonischemic central retinal vein occlusion (crvo). design : a prospective interventional case series. patients & methods : twenty eyes of 25 patients with nonischemic crvo and macular edema with visual acuity o...

A 41-year-old man was referred with a complaint of visual loss in his left eye and his best corrected visual acuity was 20/80. Slit lamp examination showed arborizing conjunctival vessels and dry eye. Fundus examination and fluorescein angiography revealed a non-ischemic central retinal vein occlusion. Cardiovascular, rheumatologic, and hematologic work up showed no abnormal findings. An ascert...

The records of 57 patients with recent central retinal vein occlusion were reviewed in order to predict the development of rubeosis iridis (RI) and neovascular glaucoma (NVG) from the initial clinical examination, colour fundus photographs, and fluorescein angiograms. Twelve patients (21 %) developed both RI and NVG, and this complication appeared to be correlated most significantly with clinic...