We propose a new role of retinoblastoma protein as a cell growth activator in its phosphorylated form. The hyper-phosphorylated retinoblastoma protein generated by the action of cdk2/cyclin E strongly stimulated the activity of DNA polymerase alpha, but did not stimulate DNA polymerases delta, epsilon, or primase. But, cdk4/cyclin D-phosphorylated retinoblastoma protein showed little stimulatio...

Retinoblastoma is the most common intraocular malignancy in children, with a reported incidence ranging from 1 in 15,000 to 1 in 18,000 live births. It is second only to uveal melanoma in the frequency of occurrence of malignant intraocular tumors. Pawius described retinoblastoma as early as in 1597 referred to the tumor as fungus hematodes and suggested enucleation as the primary mode of manag...

Retinoblastoma is a pediatric cancer that has served as a paradigm for tumor suppressor gene function. Retinoblastoma is initiated by RB gene mutations, but the subsequent cooperating mutational events leading to tumorigenesis are poorly characterized. We investigated what these additional genomic alterations might be using human retinoblastoma samples and mouse models. Array-based comparative ...

PURPOSE Forty percent of cases of retinoblastoma, a childhood malignancy of the retina, are linked to the inheritance of a mutant allele of the retinoblastoma susceptibility gene Rb1. Tumor penetrance varies among carriers in different family pedigrees, indicating that other genetic factors may modify risk for occurrence of retinoblastoma. This study was undertaken to determine whether multiple...

Retinoblastoma is a highly invasive malignant tumor that often invades the brain and metastasizes to distal organs through the blood stream. Invasiveness and metastasis of retinoblastoma can occur at the early stage of tumor development. However, an optimal preclinical model to study retinoblastoma invasiveness and metastasis in relation to drug treatment has not been developed. Here, we develo...

background: retinoblastoma is the most common intraocular tumor in childhood and mutation in the rb1 gene will trigger the tumorigenesis. so far, a wide range of the mutations along the length of rb1 gene have been reported. however, some could not be detected by common detection methods. in such condition, linkage analysis using microsatellite markers is suggested to trace unknown rb1 mutation...

purpose : to introduce a novel classification system for the extent of choroid invasion and to analyze the incidence of histopathologic risk factors (hrfs) in the patients with retinoblastoma in china methods : the clinical data of 104 enucleated eyes diagnosed with retinoblastoma were retrospectively reviewed, and the pathological re-examination of the enucleated eyes was conducted. results : ...

purpose : the first report of electroretinographic changes following the intravitreal injection of carboplatin in a patient with retinoblastoma case report : recurrent tumors after chemoreduction and adjunctive local treatment in a case of familial unilateral retinoblastoma, group c, was treated with intravitreal carboplatin (10 µg) injections. results : the tumor was regressed after 3 injectio...

purpose : to describe the survival characteristics and prognostic factors of patients with retinoblastoma in a referral center in iran methods : from medical records, we retrospectively analyzed the data of 139 consecutive children diagnosed in our hospital between 1991 and 2001 as having retinoblastoma. information on gender, laterality, age at diagnosis, presenting signs, tumor staging, treat...

in this issue of iranian journal of ophthalmology (irjo) han yue et al1 from china have presented a very interesting investigation on “histopathologic risk factors of retinoblastoma: a retrospective study of 104 enucleated eyes” which we are very grateful of the authors. before indicating few points about this article and their pathologic classification it is worthwhile to mention the “proceedi...