BACKGROUND Considering the observations that linoleic acid conjugated with paclitaxel (CLA-PTX) possesses antitumor activity against brain tumors, is able to cross the blood-brain barrier, but has poor water solubility, the purpose of this study was to prepare a novel CLA-PTX microemulsion and evaluate its activity against brain tumors in vitro and in vivo. METHODS The in vitro cytotoxicity o...

The goal of this study was to develop a parenteral microemulsion formulation of cyclosporine A (CyA). The CyA solubility in caprylic capric triglyceride (GTCC), ethyl oleate and soybean oil were determined. The pseudo-ternary diagrams of oil (GTCC), surfactant (Solutol® HS-15), cosurfactants (ethanol/polyethylene glycol 400 [PEG 400] mixture) and water were constructed to identify boundaries fo...

Solvation dynamics in a neat ionic liquid, 1-pentyl-3-methyl-imidazolium tetra-flouroborate ([pmim][BF4]) and its microemulsion in Triton X-100 (TX-100)/benzene is studied using femtosecond up-conversion. In both the neat ionic liquid and the microemulsion, the solvation dynamics is found to depend on excitation wavelength (lambda(ex)). The lambda(ex) dependence is attributed to structural hete...

PURPOSE The purpose of this study was to predict microemulsion structures by creating two artificial evolutionary neural networks (ANN) combined with a genetic algorithm. The first ANN would be able to determine the type of microemulsion from the desired composition, and the second to determine the type of microemulsion directly from a differential scanning calorimetry (DSC) curve. METHODS Th...

A novel functional KH₂PO₄ (KDP) aqueous solution-in-oil (KDP aq/O) microemulsion system for KDP crystal ultra-precision chemical-mechanical polishing (CMP) was prepared. The system, which consisted of decanol, Triton X-100, and KH₂PO₄ aqueous solution, was available at room temperature. The functional KDP aq/O microemulsion system was systematically studied and applied as polishing solution to ...

In this work, M-doped TiO2 nanostructures (M: Fe, Co and Ni) were synthesized by reverse microemulsion method. The as-prepared products were analyzed by different techniques such as scanning electron microscopy (SEM), Transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FT-IR). The effect of various dopants (Fe, Co and Ni) on ba...

The objective of this study was to design and develop o/w microemulsion for transdermal delivery of poorly water soluble acyclovir by aqueous titration method. Oleic acid: castor oil (3:1), tween 80, and ethanol were selected as oily phase, surfactant and cosurfactant respectively. The Pseudoternary phase diagrams were constructed by aqueous titration method. The cosurfactant affect the shape a...

the paper is focused on the formation of hydroxyapatite nanoparticles (hap) in polyelectrolyte-modified microemulsions, in a microemulsion template phase consisting of cyclohexane, water, cationic surfactant and cosurfactant, in the presence of na-polyacrylate (paa) as an anionic polyelectrolyte. it is shown that paa, can be incorporated into the individual inverse microemulsion droplets. the m...

The oxidation of beta-D-glucose by the enzyme glucose oxidase was studied in aqueous medium, in solutions of surfactants AOT (2-ethylhexylsulfosuccinate, sodium salt) TX-100 (polyethylene glycol p-tert octyl phenyl ether) and in w/o microemulsion medium (water/AOT/decane) at different water/AOT mole ratio (omega), pH, temperature and in presence of additives. The time-dependent activities of th...

The purpose of this study was to prepare a novel paclitaxel (PTX) microemulsion containing a reduced amount of Cremophor EL (CrEL) which had similar pharmacokinetics and antitumor efficacy as the commercially available PTX injection, but a significantly reduced allergic effect due to the CrEL. The pharmacokinetics, biodistribution, in vivo antitumor activity and safety of PTX microemulsion was ...