Abstract Introduction Cardiac disease induces remodelling which can include fibrosis, cardiomyocyte hypertrophy, cardiac dilation, and finally lead to heart failure. Age is one of the main risk factors cardiovascular remodelling, in particular, it has profound effects on microcirculation. Pericytes are microvascular mural cells involved maintenance stability homeostasis vascular network. Althou...

Cancer-associated fibroblasts (CAFs) are a key component of the tumor microenvironment and play an important role in disease progression treatment outcome. Here we used single-cell transcriptomics, CNV analysis, situ stainings to elucidate yet unresolved intra-tumoral CAF heterogeneity melanoma, basal squamous cell carcinoma. We identified three major subtypes, with their presence being indicat...

Cancer-associated fibroblasts (CAFs) play a key role in disease progression and treatment outcome. We used single-cell transcriptomics, CNV analysis, andin situ stainings to elucidate the yet unresolved intra-tumoral CAF heterogeneity melanoma non-melanoma skin cancer (basal squamous cell carcinoma, BCC SCC). identified three major subtypes, with their presence being indicative for tumor malign...