background: there is a hypothesis that people with rheumatoid arthritis (ra) can also be at risk of periodontal disease. this study aimed to assess the periodontal health in patients with and without rheumatoid arthritis. methods and materials: thirty ra patients with ra and 30 healthy individuals without ra were included. information regarding demographic characteristics and periodontal parame...

Bone is a target in many inflammatory rheumatic diseases, such as rheumatoid arthritis (RA) and ankylosing spondylitis (AS). The generalized effect of inflammation on bone may result in a decreased quality of bone and is associated with an increased risk of fractures and deformities, both in RA and AS. RA is characterized by periarticular osteopenia, systemic osteoporosis and bone erosions. Per...

Background: Obesity is one of the causes of onset and exacerbation of rheumatoid arthritis. However, limited studies have examined the association between body composition and severity of disease. The aim of this study was to evaluate the association between severity of rheumatoid arthritis with various types of obesity and the comparison of anthropometric indices between patients with rheumato...

Osteoporosis is responsible for a significant burden both individually and socially, but is readily treated with antiresorptive agents and mineral supplementation. However, long-term usage of these agents, notably bisphosphonates, is rarely associated with atypical fractures. Denosumab is a monoclonal antibody that reduces osteoclast activity and thus increases bone mineral density. In this cas...

Rheumatoid arthritis represents an excellent model in which to gain insights into the local and systemic effects of joint inflammation on skeletal tissues. Three forms of bone disease have been described in rheumatoid arthritis. These include: focal bone loss affecting the immediate subchondral bone and bone at the joint margins; periarticular osteopenia adjacent to inflamed joints; and general...

Background: There is no clear consensus regarding the potential of denosumab for increasing the risk of infection in patients who concurrently receive biologic disease-modifying anti-rheumatic drugs (bDMARDs). In this study, we compared the rate of infection in postmenopausal women with rheumatoid arthritis who received concurrent bDMARDs and denosumab with those who received bDMARDs alone.   ...

background :to estimate the prevalence and characteristics of rheumatoid arthritis (ra) in an urban area of tehran.   methods : a total of 50 clusters were randomly selected in tehran and 10291 subjects completed the copcord core questionnaire during 2004 and 2005. patients with rheumatic complaints were examined and diagnosed by subspecialty fellows in rheumatology. laboratory and radiology te...