نتایج جستجو برای: ribonucleoprotein
تعداد نتایج: 6284 فیلتر نتایج به سال:
Tylophorine compounds have been the focus of drug development for decades. Tylophorine derivatives exhibit anti-cancer activities but their cellular targets remain unknown. We used a biotinylated tylophorine derivative to probe for the interacting cellular target(s) of tylophorine. Tylophorine directly binds to caprin-1 and consequently enhances the recruitment of G3BP1, c-Myc mRNA, and cyclin ...
There is abundant chemical (1) and morphological (2-4) evidence which suggests that the bulk of the ribonucleic acid of rat liver is concentrated in discrete particles that occur associated with the membranes of the endoplasmic reticulum. Studies both in viva and in vitro have indicated that labeled amino acids are incorporated into the proteins of these particles at more rapid rates than into ...
The LINE-1 retrotransposon (L1) encodes two proteins, ORF1p and ORF2p, which bind to the L1 RNA in cis, forming a ribonucleoprotein (RNP) complex that is critical for retrotransposition. Interactions with both permissive and repressive host factors pervade every step of the L1 life cycle. Until recently, limitations in detection and production precluded in-depth characterization of L1 RNPs. Ind...
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