The number of new psychoactive substances (NPS) on the illicit drug market increases fast, posing a need to urgently understand their toxicity and behavioural effects. However, with currently available rodent models, NPS assessment is limited few per year. Therefore, zebrafish (Danio rerio) embryos larvae have been suggested as an alternative model that would require less time resources perform...

The use of animal models for substance disorder (SUD) has made an important contribution in the investigation behavioral and molecular mechanisms underlying abuse addiction. Here, we review a novel comprehensive platform to characterize addiction-like traits rodents using fully automated learning system, IntelliCage. This system simultaneously captures basic navigation, reward preference, avers...

Rodents show an immense variation in reproductive seasonality, spanning the whole spectrum from strictly seasonal to continuous reproduction throughout year. However, factors causing this have so far mostly been investigated single-species studies that could not address phylogenetic constraints. By applying both a categorical description and quantitative measure, present study characterises deg...

Objective: Chronic mild stress is the most valid model in inducing depression rodents. In this method, rats were subjected to CMS for 6 weeks of stress. Methods: rodents a series stressors six an unpredictable manner. Results: Biochemical and pathological changes observed. Lycopene treatment at 10 mg/kg 20 could revert these biochemical changes. Histopathological studies showed there neuronal l...