Hepatocyte growth factor (HGF) and its tyrosine kinase receptor Met play a pivotal role in the tumor metastatic phenotype and represent attractive therapeutic targets. We investigated the biochemical and biological effects of the tyrosine kinase inhibitor RPI-1 on the human lung cancer cell lines H460 and N592, which express constitutively active Met. RPI-1-treated cells showed down-regulation ...

Diabetes detrimentally affects the musculoskeletal system by stiffening the collagen matrix due to increased advanced glycation end products (AGEs). In this study, tibiae and tendon from Zucker diabetic Sprague-Dawley (ZDSD) rats were compared to Sprague-Dawley derived controls (CD) using Atomic Force Microscopy. ZDSD and CD tibiae were compared using Raman Spectroscopy and Reference Point Inde...

3:00 p.m. with a pre-reception at 2:30 p.m. D’ Ambra Auditorium Established through the generosity of UAlbany Distinguished Professor Marlene Belfort and RPI Institute Professor Georges Belfort, the Life at the Interface of Science and Technology Endowed Lecture Series is designed to address fundamental questions that require the expertise of both Life Sciences and Engineering to answer. This c...

I examine the relationship between analysts’ use of public information and the performance of their stock recommendations. I construct a measure of analysts’ reliance on public information (RPI) based on the sensitivity of their recommendation revisions to quantitative variables that are known to predict returns. I find a strong negative relationship between analysts’ past RPI and their future ...

Pathogen attack and the plant's response to this attack affect herbivore oviposition preference and larval performance. Introduction of major resistance genes against Phytophthora infestans (Rpi-genes), the cause of the devastating late blight disease, from wild Solanum species into potato changes the plant-pathogen interaction dynamics completely, but little is known about the effects on non-t...

A parallel converter architecture based on the resonant pole inverter (RPI) topology is presented. It is shown that this architecture minimizes the output magnetics required for current sharing. A new current control scheme is introduced which reduces peak currents, losses, and output voltage ripple for many operating conditions. This new control method is applicable to both the single RPI and ...

Regional perfusion imaging (RPI) based on pulsed arterial spin labeling and angulated inversion slabs has been recently proposed. The technique allows mapping of individual brain perfusion territories of the major feeding arteries and could become a valuable clinical tool for evaluation of patients with cerebrovascular diseases. Here we propose a new labeling scheme for RPI where lateral and po...

An indicator model for evaluating trends in river quality using a two-stage fuzzy set theory to condense efficiently monitoring data is proposed. This candidate data reduction method uses fuzzy set theory in two analysis stages and constructs two different kinds of membership degree functions to produce an aggregate indicator of water quality. First, membership functions of the standard River p...

Isoelectric solubilization/precipitation (ISP) processing allows selective, pH-induced water solubility of proteins with concurrent separation of lipids and removal of materials not intended for human consumption such as bone, scales, skin, etc. Recovered proteins retain functional properties and nutritional value. Four roe protein isolates (RPIs) from yellowfin tuna roe were prepared under dif...