Rat promegakaryoblasts (RPM, a precursor platelet cell line) in culture exhibited a capacity to bind, take up and degrade 125I-LDL. The low density lipoprotein (LDL) binding showed the following characteristics: (a) high affinity, (b) saturability, (c) specificity, (d) down-regulation, after exposure to 25 hydroxycholesterol. Furthermore the proteolytic degradation of 125I-LDL by RPMs was inhib...

Vascular smooth muscle cell (VSMC) phenotypic modulation is a key factor in vascular pathology. We have investigated the role of Notch receptor signaling in controlling human vascular smooth muscle cell (hVSMC) differentiation in vitro and established a role for cyclic strain-induced changes in Notch signaling in promoting this phenotypic response. The expression of alpha-actin, calponin, myosi...

While brain stimulation techniques have been examined as treatment options for chronic tinnitus for many years, they have recently been extended to multimodal treatment approaches. As chronic tinnitus is often accompanied by comorbid muscular tension in the neck and back, we performed a one-arm pilot study to explore the feasibility of a new multimodal treatment approach. In detail, repetitive ...

With fast-paced digital transformation, precision medicine has been an essential part to elevate the conscience of healthcare with respect biopsychosocial model help Remote Patient Monitoring Systems. Digital twins have successful in many industries, healthcare, it can optimize wellness human body improve physical and mental including non-diagnosed diseased populations rural populations.
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The journal bearing test rig is used for experimental research to evaluate the effect of various speeds and loads utilizing two distinct fluids, SAE 30 Ferro Fluid. lubricant mobility on a loaded investigated, metrics such as coefficient friction, load capacities, pressure are calculated better understand nature both lubricants. Three introduced setup at three different rpms: 500, 600, 700. A t...

RAPOC (Rosseland and Planck Opacity Converter) is a Python 3 code that calculates Rosseland mean opacities (RPMs) from wavelength-dependent for given temperature, pressure, wavelength range. In addition to being user-friendly rapid, can interpolate between discrete data points, making it flexible widely applicable the astrophysical Earth-sciences fields, as well in engineering. For input data, ...

Abstract Railway point machine (RPM) condition monitoring has attracted engineers’ attention for safe train operation and accident prevention. To realize the fast accurate fault diagnosis of RPMs, this paper proposes a method based on entropy measurement broad learning system (BLS). Firstly, modified multi-scale symbolic dynamic (MMSDE) module extracts characteristics from collected acoustic si...