The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA. In response to insulin, eIF4B is phosphorylated on Ser422 by S6K in a rapamycin-sensitive manner. Here we demonstrate that the p90 ribosomal protein S6 kinase (RSK) phosphorylates eIF4B on the same residue. The relative contribution of the RSK and S6K modules to the...

Kaposi’s sarcoma (KS) is a common malignancy in untreated AIDS patients that is caused by the infection of Kaposi’s sarcoma-associated herpesvirus (KSHV). KS lesions are characterized by spindle-shaped endothelial cells with infiltration of inflammatory cells and neoangiogenesis. KSHV commonly establishes default latent infection, but lytic replications occur in a small fraction of cells and pl...

Abstract We clarify the links between graded Specht construction of modules over cyclotomic Hecke algebras and Robinson-Schensted-Knuth (RSK) for quiver type $A$, which was recently imported from setting representations $p$-adic groups. For that goal we develop a theory crystal derivative operators on algebra categorifies Berenstein–Zelevinsky strings framework quantum groups generalizes varian...

Objective—Angiotensin II (Ang II) promotes vascular inflammation and remodeling via activation of nuclear factor B (NFB)–mediated transcription of proinflammatory genes such as interleukin-6 (IL-6). We examined the signaling mechanism whereby Ang II activates NFB in vascular smooth muscle cells (VSMCs). Methods and Results—Ang II treatment did not increase phosphorylation of inhibitor of B (I B...

Mitogen-activated protein kinase (MAPK) signaling regulates fundamental cellular functions including proliferation, differentiation, and survival. We have demonstrated previously that inhibiting MAPK signaling induces apoptosis in melanoma cells but not in normal melanocytes, suggesting that the MAPK pathway propagates essential survival signals in melanoma cells. Here, we report that the 90-kD...

Integration of the Salmonella typhimurium virulence plasmid into the chromosome reduces mouse virulence, serum resistance, and HeLa cell adhesion-invasion while prolonging lag time in minimal medium. The proposed virulence plasmid regulatory element, rsk, partially restores virulence and fully restores the other three phenotypes to wild-type levels. Plasmid curing reduces virulence without affe...

BACKGROUND Existence of bacterial host-cell DNA contamination in biopharmaceutical products is a potential risk factor for patients receiving these drugs. Hence, the quantity of contamination must be controlled under the regulatory standards. Although different methods such as hybridization assays have been employed to determine DNA impurities, these methods are labor intensive and rather expen...

Y-box binding protein-1 (YB-1) is the first reported oncogenic transcription factor to induce the tumor-initiating cell (TIC) surface marker CD44 in triple-negative breast cancer (TNBC) cells. In order for CD44 to be induced, YB-1 must be phosphorylated at S102 by p90 ribosomal S6 kinase (RSK). We therefore questioned whether RSK might be a tractable molecular target to eliminate TICs. In suppo...

We introduce a set of operations that we call crystal operations on matrices with entries either in {0, 1} or in N. There are horizontal and vertical forms of these operations, which commute with each other, and they give rise to two different structures of a crystal graph of type A on these sets of matrices. They provide a new perspective on many aspects of the RSK correspondence and its dual,...

In this paper we compute the orbits of the symplectic group Sp2n on partial flag varieties GL2n/P and on partial flag varieties enhanced by a vector space, C ×GL2n/P . This extends analogous results proved by Matsuki on full flags. The general technique used in this paper is to take the orbits in the full flag case and determine which orbits remain distinct when the full flag variety GL2n/B is ...