Persistent stimulation of immunocompetent cells, such as histocompatibility reactions, may be one of the causes of neoplastic proliferation of lymphoreticular tissues. In the present studies, the graft-versus-host reaction was induced in 18week-old male ( C 57 Bl/6] x DBA/2 J )F1 mice · by two or four weekly intraperitoneal injections of approximately 80 x 106 male C 57 Bl/6 J or C 57 Bl/Na mou...

Newborn rats of one inbred strain were given an intracardiac injection of adult thoracic duct lymphocytes from another inbred strain. It was found that although there was a direct relationship between the number of small lymphocytes injected and the incidence of fatal runt disease, there was no particular relationship between the large lymphocyte content of an inoculum and its runt-inducing pot...

Thymectomy of Sprague-Dawley rats on the 3rd day of life failed to influence the time of onset, incidence, clinical, or histologic picture of runt disease produced by the intraperitoneal injection of adult Long-Evans spleen cells. The fact that severe immunologic impairment of the host by thymectomy does not modify runt disease was felt to be consistent with the current view that the if directi...

Runt piglets were used as a model for neonatal stress to test the hypothesis that stress during the pre-weaning period can alter adipokine gene transcription levels. Runts were selected by birth mass <1kg and compared to littermates (controls) of mean litter weight. Subcutaneous (SQ) and perirenal (PR) adipose tissues were collected at d1 (n=5), d7 (n=7) or d21 (n=9) of age. Real time PCR was u...