Despite a plethora of information system development (ISD) methods available, organisations are seldom satisfied with methods taken as given. Surveys as well as case studies on method development and CASE tool use reveal that organisations tend to develop their own "variants" of methods, or interpret methods available according to their situation specific needs (cf. Aaen et al. 1992, Russo & Wy...

Russo and Williamson (2007) put forward the thesis that, at least in the health sciences, to establish the claim that C is a cause of E one normally needs evidence of an underlying mechanism linking C and E as well as evidence that C makes a difference to E. This epistemological thesis poses a problem for most current analyses of causality which, in virtue of analysing causality in terms of jus...

Determining how findings of chemically induced carcinogenic effects in rodents can properly be interpreted for human health poses a continuing challenge to the risk assessment community. One approach begins by comparing and contrasting carcinogenic process in rodents and humans, identifying biologically significant similarities and differences and gaps in scientific knowledge and understanding....

Suppose that X1, . . . , Xn are continuous semimartingales that are reversible and have nondegenerate crossings. Then the corresponding rank processes can be represented by generalized Stratonovich integrals, and this representation can be used to decompose the relative log-return of portfolios generated by functions of ranked market weights. Introduction For n ≥ 2, consider a family of continu...

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Figurate Paraneoplastic Urticaria and Prostate Cancer Adone Baroni, M.D., Ph.D., Franco Fac...