The safety assessment of Nuclear Power Plants makes use of Thermal-Hydraulic codes for the quantification of the safety margins with respect to upper/lower safety thresholds, when postulated accidental scenarios occur. To explicitly treat uncertainties in the safety margins estimates within the Risk-Informed Safety Margin Characterization (RISMC) framework, we resort to the concept of Dynamic P...

Anticonvulsant activity of N-(p-aminobenzoyl)-1,2,3,4- tetrahydro-quinoline (NTQ), a newly synthesized ameltolide analog, was investigated with regards to efficacy and toxicity in mice. Additionally, its effect on NMDA receptors was also performed on NR1a/NR2B expressed in Xenopus oocytes. NTQ, given intraperitoneally, was able to protect the animals in both maximal electroshock seizure and pen...

Anticonvulsant activity of N-(p-aminobenzoyl)-1,2,3,4- tetrahydro-quinoline (NTQ), a newly synthesized ameltolide analog, was investigated with regards to efficacy and toxicity in mice. Additionally, its effect on NMDA receptors was also performed on NR1a/NR2B expressed in Xenopus oocytes. NTQ, given intraperitoneally, was able to protect the animals in both maximal electroshock seizure and pen...

We present a new decision rule, maximin safety, that seeks to maintain a large margin from the worst outcome, in much the same way minimax regret seeks to minimize distance from the best. We argue that maximin safety is valuable both descriptively and normatively. Descriptively, maximin safety explains the well-known decoy effect, in which the introduction of a dominated option changes preferen...

We propose that the critical function of sleep [3] is to prevent uncontrolled neuronal feedback while allowing rapid responses and prolonged retention of short-term memories. The goal of learning is optimal behavior, and this sometimes requires the integration of sensory stimuli that are widely separated in time. At a neuronal level, this corresponds to persistent activity in local networks. Un...

Pedestrian-motor vehicle collisions account for over 6% of all workplace fatalities and are the leading cause of work related traumatic injury among highway workers. Interventions to reduce these accidents have focused primarily on vision. However, given the high demands on the visual attention of both pedestrian workers and vehicle operators, auditory warning might be a fruitful avenue for the...

In this paper, the safety margin of seismically isolated buildings (SIBs) is probabilistically evaluated using Incremental Dynamic Analysis (IDA), and effect laminated rubber bearing’s hardening characteristics on SIBs also verified quantitatively. As a result, since non-consideration overestimates margin, it important to consider in evaluation superstructure’s margin. Also, tendency by IDA und...

The objective of this study was to use audited hospital financial statements to identify predictors of payer mix and financial performance in safety net hospitals prior to the Affordable Care Act. We analyzed the 2010 financial statements of 98 large, urban safety net hospital systems in 34 states, supplemented with data on population demographics, hospital features, and state policies. We used...

Tumor recurrence in hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA) remains common; some studies have reported that insufficient ablative margin after RFA might contribute to HCC recurrence. The aim of this study was to investigate whether insufficient ablative safety margins determined by early computed tomography (CT) predicts HCC recurrence after RFA. This retrosp...