We introduce Weinberg’s idea of asymptotic safety and pave the way towards an asymptotically safe chiral Yukawa system with a U(NL)L⊗U(1)R symmetry in a leading-order derivative expansion using nonperturbative functional RG equations. As a toy model sharing important features with the standard model we explicitely discuss NL = 10 for which we find a non-Gaußian fixed point and compute its criti...

Safety cases offer a means for communicating information about the system safety among the system stakeholders. Recently, the requirement for a safety case has been considered by regulators for safety-critical systems. Adopting safety cases is necessarily dependent on the value added for regulatory authorities. In this work, we outline a structured approach for assessing the level of sufficienc...

Aluminum-containing adjuvants are widely used in preventive vaccines against infectious diseases and in preparations for allergy immunotherapy. The mechanism by which they enhance the immune response remains poorly understood. Aluminum adjuvants selectively stimulate a Th2 immune response upon injection of mice and a mixed response in human beings. They support activation of CD8 T cells, but th...

The study develops an analytical model of emissions markets equipped with a safety valve mechanism. It examines the regulator’s control of emission reductions by emitters by setting two policy parameters: emission targets and trigger prices. We show that the capabilities of these two policy tools are greatly affected by uncertainty regarding unconstrained aggregate emissions. We also show that ...

Paracetamol/acetaminophen is one of the most popular and most commonly used analgesic and antipyretic drugs around the world, available without a prescription, both in mono- and multi-component preparations. It is the drug of choice in patients that cannot be treated with non-steroidal anti-inflammatory drugs (NSAID), such as people with bronchial asthma, peptic ulcer disease, hemophilia, salic...

Safety Dai Liang  (Department of Philosophy of Science and Technology, University of Science and Technology of China, Hefei, Anhui,China 230026) Abstract: In this paper, by analyzing the relationship between unemployment, poverty and environmental safety, it reveals the cross-cutting among the social problems, which concludes environmental degradation, poverty and unemployment. We can expand t...

Vaccines are some of the most effective tools for the prevention of infectious diseases. Adjuvants are included in vaccines for a variety of reasons: to increase the breadth of response, to lower antigen dose, to overcome limited immune response in some populations, or to enable complex combination vaccines. This study aims to review the safety of licensed vaccine adjuvants and describe their m...

A handheld, portable cranial drilling tool for safely creating holes in the skull without damaging brain tissue is presented. Such a device is essential for neurosurgeons and mid-level practitioners treating patients with traumatic brain injury. A typical procedure creates a small hole for inserting sensors to monitor intra-cranial pressure measurements and/or removing excess fluid. Drilling ho...

Device drivers typically execute in supervisor mode and thus must be fully trusted. This paper describes how to move them out of the trusted computing base, by running them without supervisor privileges and constraining their interactions with hardware devices. An implementation of this approach in the Nexus operating system executes drivers in user space, leveraging hardware isolation and chec...