Benzoic acids are highly important structural motifs in drug molecules and natural products. Selective C-H bond functionalization of benzoic acids will provide synthetically useful tools for step-economical organic synthesis. Although direct ortho-C-H functionalizations of benzoic acids or their derivatives have been intensely studied, the ability to activate meta-C-H bond of benzoic acids or t...

Hyperosmolar food causes atherosclerosis. Hyperosmolal food hypothesis encompasses all the factors involved under one heading and, that is, the generation of heat in the body. The involvement of cigarette smoking is obvious. High glycemic index food and diabetes result in high levels of blood glucose, which raises the core body temperature. The ingestion of hyperosmolal salt, glucose, and amino...

The effects of brine concentration (8%, 12%, 16% and 20%) ageing (0 12 months) Korean traditional doenjang (fermented soybean paste) on metabolite profiles their relationship with consumer acceptance were investigated. Using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry gas chromatography–mass spectrometry, we identified 26 31 metabolites, respectively. Aft...

BACKGROUND Fatty acids are known to be critically important in multiple biological functions. Phospholipid fatty acids of follicular fluid, an important microenvironment for the development of oocytes, may contribute to the women's fertility and the efficacy of assisted reproduction techniques. The aim of this study was to investigate the effect of fatty acid composition of follicular fluid pho...

Corn gluten meal, a corn processing industry by-product, is a good source for the preparation of bioactive peptides due to its special amino acid composition. In the present study, the in vitro and cellular free radical scavenging activities of corn peptide fractions (CPFs) were investigated. Results indicated that CPF1 (molecular weight less than 1 kDa) and CPF2 (molecular weight between 1 and...

The presence of dissolved salt during the enzymatic aminoacylation of transfer RNA diminishes the amount of aminoacyl-tRNA formed at the completion of the reaction. Experiments indicate that, although salt inhibits aminoacyltRNA synthetases, the diminution of the final level of aminoacylation is the result of salt-dependent changes in tRNA. tRNAs accepting different amino acids differ widely in...

background: fat-rich diet may alter oocyte development and maturation and embryonic development by inducing oxidative stress (os) in follicular environment. objective: to investigate the relationship between fat intake and oxidative stress with oocyte competence and embryo quality. materials and methods: in observational study follicular fluid was collected from 236 women undergoing assisted re...

In this study, Asphodelus tenuifolius (ATO) seeds oils were extracted by three different extraction methods, namely Soxhlet (SE), microwave-assisted (MAE) and ultrasonic-assisted (UAE). The physicochemical properties, fatty acids, sterols, tocols, total phenol content antioxidant activity of ATO seed examined compared. best yield was from SE (21.97 ± 0.01%), followed MAE (19.28 0.13%) while tha...

The response of Desulfovibrio vulgaris Hildenborough to salt adaptation (long-term NaCl exposure) was examined by performing physiological, global transcriptional, and metabolite analyses. Salt adaptation was reflected by increased expression of genes involved in amino acid biosynthesis and transport, electron transfer, hydrogen oxidation, and general stress responses (e.g., heat shock proteins...

We recently reported that an enzyme of the cytochrome P-450 4A family is expressed in the glomerulus, but there is no evidence that 20-hydroxyeicosatetraenoic acid (20-HETE) can be produced by this tissue. The purpose of present study was to determine whether glomeruli isolated from the kidney of rats can produce 20-HETE and whether the production of this metabolite is regulated by nitric oxide...