The acronym of SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) combines a cluster of cutaneous and musculoskeletal manifestations, such as hyperostosis of bones of the anterior chest wall associated with acne fulminans and hidradenitis suppurativa. There are no validated diagnostic criteria in children. Nonsteroidal anti-inflammatory drugs are not always sufficient, and ...

Background Chronic nonbacterial osteomyelitis (CNO) is a rare bone disease characterized by sterile inflammation and locally increased turnover. CNO that occurs in the rheumatic spectrum of synovitis, acne, pustulosis, hyperostosis osteitis referred to as SAPHO syndrome [1, 2]. To date, there are no objective biomarkers for monitoring activity. Recommended imaging tools like technetium radiolab...

We report the case of a 50-year-old Japanese woman with SAPHO (synovitis-acne-pustulosis-hyperostosisosteomyelitis) syndrome. Radiographs showed osteosclerosis of the cervical and lumbar vertebrae, as well as osteosclerosis and osteolysis of the right femoral neck, resembling multiple metastatic bony lesions. Arriving at a diagnosis required hematological and imaging tests. Whole-body bone scin...

Sternocostoclavicular hyperostosis (SCCH) is a chronic osssifying diathesis affecting mostly juxtasternal structures and the inflammatory osteitis part of synovitis, acne, pustulosis, hyperostosis, (SAPHO) syndrome.

Introduction SAPHO syndrome is defined as the association of a group of rare sterile osteoarticular disorders and inflammatory skin diseases whose etiology, although not yet determined, probably involves genetic, immunological and infectious mechanisms. The recurrent multifocal osteomyelitis, an inflammatory disease, can be associated with this syndrome even as a single event. Case Report A c...

Introduction: SAPHO syndrome is defined as the association of a group of rare sterile osteoarticular disorders and inflammatory skin diseases whose etiology, although not yet determined, probably involves genetic, immunological and infectious mechanisms. The recurrent multifocal osteomyelitis, an inflammatory disease, can be associated with this syndrome even as a single event.  Case Report:...