Jiaogulan (Gynostemma pentaphyllum; GP) contained a saponin glycoside which was related to ginseng saponin. The purpose of this study was to identify the main saponin in water extract GP compared to methanol and ethanol extract. The sample was prepared by alkaline cleavage, trimethylsilyl (TMS) derivatization and gas chromatographic-mass spectrometric (GC-MS) analysis comparison with standard g...

Two natural saponins 1 and 2, isolated from Solanum indicum L., and containing 2,3-branched sugar moieties, have been efficiently synthesized. Partially protected monosaccharide and disaccharide donors were used to facilitate target synthesis. Stereo factors were critical in incorporating 2,3-branched sugars on steroid aglycones. Saponin 1 was synthesized in five steps and 30% overall yield, wh...

In a previous study by Omura and Osogoe (1951), it has been shown that in acute saponin poisoning in rabbits, injury to sinusoidal walls opens the bone marrow parenchyma to the blood current and the marrow cells are depleted to a large extent. Since the mode of reaction of the reticuloendothelial (RE) cells lining the sinusoidal walls in the bone marrow and liver to saponin is still unknown, th...

Background: Saponins identified from fenugreek (Trigonella foenum-graecum) seeds are reported effective on dyslipidemia. However, the definite mechanism is still not elucidated systematically. In this study, we evaluate the effects of saponin extract on cholesterol absorption, metabolism, synthesis, and reverse cholesterol transport in vivo.Methods: Saponin extract was prepared according to a c...

1. The susceptibility of mice to the lethal effect of preparations containing the oxygen-labile hemolysin (streptolysin O) of group A hemolytic streptococci has been studied. Injection of a single sublethal dose of the streptococcal preparation causes the development of resistance to the effect of a lethal dose injected subsequently. 2. Resistance is demonstrable 3 to 6 hours after the injectio...

since the use of antibiotics in animal feeds has been banned, researches on alternative natural products that modulate ruminal fermentation have been intensified. natural compounds such as plant extracts have been considered to be replaced antibiotics as safe and sustainable alternatives. plant extracts especially essential oils and saponins have strong antimicrobial, antiparasitic, antiprotozo...

Phytochemical study of the ethanol extract of the seeds of Aesculus chinensis led to the isolation of a new triterpenoid saponin (6), together with five known triterpenoid saponins (1-5). The structure of the new compound was elucidated on the basis of spectral data to be 21,28-di-O-acetylprotoaescigenin-3-O-[beta-D-glucopyranosyl(1-2)][beta-D-glucopyranosyl(1-4)]-beta-D-glucopyranosiduronic ac...

Ginseng (Panax ginseng C.A. Meyer) is one of the most potent medicinal plants and has been used for centuries as a health tonic. Saponin is considered one of the most important active components in ginseng root, which shows anabolic, adaptogenic, antibiotic, minor hyperglycemic, and anti-cancer activities. More than 20 different types of saponin have been identified. Current advances in plant b...

Comparative immunostimulatory properties of saponin and incomplete Freund's adjuvant (IFA) were studied using affinity purified 39 kDa larval antigen of Hyalomma anatolicum anatolicum. Significant antibody response to 39 kDa antigen was detected in the sera of rabbits immunized with both 39 kDa plus saponin and 39 kDa plus IFA in comparison to their corresponding control animals. Insignificant ...