OBJECTIVE To prospectively characterize changes in body weight, satiety, and postprandial gut hormone profiles following esophagectomy. BACKGROUND With improved oncologic outcomes in esophageal cancer, there is an increasing focus on functional status and health-related quality of life in survivorship. Early satiety and weight loss are common after esophagectomy, but the pathophysiology of th...

A wealth of data supports the idea that the stomach and cholecystokinin octapeptide (CCK-8) normally play important roles in meal size and satiety. We studied long-term gastrectomized humans to further evaluate this possibility. Ten humans, who were gastrectomized 8 (3-12) years earlier, and eight controls ate a meal from a plate placed on a scale connected to a computer and estimated their sat...

When ingested food does not accumulate in the stomach or enter the small intestine, rats do not stop eating. Small amounts of food placed in the small intestine or intraperitoneal injections of the intestinal hormone cholecystokinin (CCK) elicit the full behavioral display of satiety in these sham-feeding rats. In rhesus monkeys, intravenous infusions of CCK produce large, dose-related reductio...

The motivation to start or terminate a meal involves the continual updating of information on current body status by central gustatory and reward systems. Previous electrophysiological and neuroimaging investigations revealed region-specific decreases in activity as the subject's state transitions from hunger to satiety. By implanting bundles of microelectrodes in the lateral hypothalamus, orbi...

Many experiments on the role of learning in the amount eaten at a distinctive test meal have been claimed to observe “conditioned satiety.” None published from outside this author’s group has used either the necessary design of the contingencies to be learnt or the measurements that distinguish a sating effect from other loss of interest in food. One experiment has just been published without a...

BACKGROUND Substituting sugar-free for sugar-sweetened beverages reduces weight gain. A possible explanation is that sugar-containing and sugar-free beverages cause the same degree of satiety. However, this has not been tested in long-term trials. METHODS We randomized 203 children aged 7-11 years to receive 250 mL per day of an artificially sweetened sugar-free beverage or a similarly lookin...

BACKGROUND Altered gastric and cholecystic motility are risk factors for malnutrition in elderly persons, mainly through impaired satiety-appetite rhythm. Contrasting data have been published about this topic. The aim of this study was to evaluate, in healthy elderly participant, postprandial gastric and cholecystic emptying in relation to serum CCK (cholecystokinin) and PYY (peptide YY), as we...

Introduction: Type 2 Diabetes (T2D) is one of the leading causes mortality with obesity being greatest risk factors. Increased protein intake has been found to increase satiety, that could potentially aid in weight control. However, much research elusive on specifics effects plant-based protein, specifically pea satiety and responses linked appetite. The purpose this review was investigate post...