G protein-coupled receptor kinases (GRKs), such as rhodopsin kinase and beta-adrenergic receptor kinase (beta ARK), are involved in mediating agonist-specific phosphorylation and desensitization of G protein-coupled receptors. GRK6 is the most recently identified member of the GRK family and displays higher homology with GRK5 (70.1% amino acid identity) and IT11 (68.5%) compared to beta ARK (37...

Transgenic mice with cardiac specific overexpression of -adrenergic receptor kinase-1 ( ARK-1) exhibit reduced contractility in the presence of adrenergic stimulation. However, whether contractility is altered in the absence of exogenous agonist is not clear. Effects of ARK-1 overexpression on contraction were examined in mouse ventricular myocytes, studied at 37°C, in the absence of adrenergic...

Many biodiversity researchers have responded to the financial constraints faced by policy makers to develop models based upon the “Noah’s Ark” metaphor, implying that society can save only a limited amount of biodiversity. Unfortunately, as Herman Daly (Land Economics, 1991) pointed out, such microeconomic rules can allow an ark to sink albeit in some optimal fashion. So, I step back to look at...

The beginning of 21 century saw file sharing of copy righted materials emerging as a major threat to the established business models of the content industry. The intellectual property rights in the real world scenario holds true in the virtual world also. This paper tries to understand the various issues of copy right violation in India. It also introduces deep packet inspection, a method to an...

In this paper, we review the Intergovernmental Panel on Climate Change and the Millennium Ecosystem Assessment Scenarios and their assumptions on biodiversity conservation, using a framework based on the cultural theory (CT) perspectives. We explored an adaptation of the CT typology and the significance of some underrepresented worldviews for discussions on conservation in a changing world. The...

For a local field K with positive residue characteristic p, we introduce, in the first part of this paper, a refinement bArK of the classical Artin distribution ArK . It takes values in cyclotomic extensions of Q which are unramified at p, and it bisects ArK in the sense that ArK is equal to the sum of bArK and its conjugate distribution. Compared with 12ArK , the bisection bArK provides a high...