In this article, small scale effects on free vibration analysis of non-uniform nanobeams is discussed. Small scale effects are modelled after Eringen’s nonlocal elasticity theory while the non-uniformity is presented by exponentially varying width among the beams length with constant thickness. Analytical solution is achieved for free vibration with different boundary conditions. It is shown th...

We present the frailtyHL package for fitting semi-parametric frailty models using hlikelihood. This package allows lognormal or gamma frailties for random-effect distribution, and it fits shared or multilevel frailty models for correlated survival data. Functions are provided to format and summarize the frailtyHL results. The estimates of fixed effects and frailty parameters and their standard ...

Targeted interventions in combination with the measurement of secondary effects can be used to computationally reverse engineer features of upstream nontranscriptional signaling cascades based on the nested effect structure. We extend previous work by Markowetz et al., who proposed a statistical framework to score hypothetical networks for this purpose. Our extensions go in several directions: ...