BACKGROUND Early detection and interventions have enabled patients with sickle cell disease (SCD) to live well into adulthood. Consequently, the chronicity of SCD allows for the insidious manifestation of multisystem complications, including renal damage. Cystic renal lesions are commonly incidentally discovered on ultrasound and computerised tomography (CT) imaging of the abdomen. Most are ben...

OBJECTIVE Children with sickle cell disease (SCD) exhibit poor somatic growth due to nutritional and metabolic effects, but potential relationships between growth and other areas of development are unclear. We examined whether growth is related to cognition and whether growth might be one marker of neurocognitive risk. METHODS Sixty-four children with SCD and eighty-one demographically simila...

Painful vaso-occlusive crises (VOCs) are the hallmark of sickle cell disease (SCD); however, many patients experience frequent daily pain that does not follow the pattern of typical VOCs. This pain of variable severity, also referred as persistent pain in the SCD literature, contributes to significant morbidity and poor quality of life and often fails to respond adequately to standard SCD thera...

OBJECTIVE To examine the impact of sickle cell disease (SCD) on academic attainment; the relation between academic attainment and achievement in SCD; and determinants of attainment in SCD. METHODS Children with SCD and demographically matched peers were compared on academic attainment. Hematocrit, illness frequency, cognitive ability, and socioeconomic status were used to model the predictors...

Sudden cardiac death (SCD) is a devastating complication of many forms of heart disease and on occasion presents in the absence of structural cardiac abnormalities. SCD caused by ventricular arrhythmias is a daunting public health problem with 200 000 to 450 000 events in the United States annually. 1 There are many challenges in the definition, mechanisms, and management of SCD that will be ad...

Fatty acid desaturases such as steaoryl-CoA desaturase (SCD) convert saturated to unsaturated fatty acids and are involved in lipogenesis. Observational and animal data suggest that SCD-1 activity is related to insulin sensitivity. However, the effects of insulin-sensitizing drugs on SCD gene expression and desaturase activities are unknown in humans. In a randomized, placebo-controlled, double...

Sickle cell disease (SCD) pain continues to emerge in adolescents. More than 98,000 individuals are believed to have SCD in the United States. In fact, 1 in 500 Black infants will be affected by SCD. Identifying standards of care for this unique population can improve pain management and treatment. A significant effect of vaso-occlusive crisis is a decrease in the quality of life in children. T...

PURPOSE Sickle cell disease (SCD) subjects have been widely reported to present with various anthropometric deficits, including malocclusion and stunting, compared to their unaffected peers. This study was carried out to examine these reports in Lagos. METHODS A hospital-based cross-sectional study was carried out in 3 outpatient SCD units of one teaching and two general hospitals. All establ...

Stearoyl-coenzyme A desaturase (SCD) catalyzes the Δ9-cis desaturation of saturated fatty acids (SFA) to generate monounsaturated fatty acids (MUFA). This enzyme is highly up-regulated by platelet-derived growth factor (PDGF) in human fibroblasts. Accordingly, the analysis of cellular fatty acids by gas chromatography showed that PDGF significantly increased the proportion of MUFA, particularly...