Schistosomiasis is a major human parasitic disease with a global impact. Schistosoma japonicum, the most difficult to control, can survive within host veins for decades. Mechanisms of immune evasion by the parasite, including antigenic variation and surface masking, have been implicated but not well defined. In this study, we defined the immunoglobulin-binding proteomes of S. japonicum using hu...

Schistosomiasis japonica is caused by the parasitic trematode Schistosoma japonicum. It is endemic in The People's Republic of China and has significant impact on human health and socioeconomic development in certain regions. Over the last six decades, the national control programmes evolved in remarkable ways and brought schistosomiasis japonica largely under control. We describe the history a...

Schistosomiasis is the most common of the trematode infections, affecting more than 200 million people worldwide.1,2 Hepatosplenic schistosomiasis occurs primarily with infection due to Schistosoma mansoni and less often with Schistosoma japonicum. If left untreated patients may ultimately develop massive hepatosplenomegaly, portal hypertension, and variceal hemorrhage.1–3 The diagnosis of hepa...

Schistosomes are the causative agents of schistosomiasis, one of the most prevalent and serious of the parasitic diseases that currently infects approximately 200 million people worldwide. Schistosome excretory/secretory (ES) proteins have been shown to play important roles in modulating mammalian host immune systems. In our current study, we performed a global proteomics identification of the ...

BACKGROUND Schistosomiasis, one of the neglected tropical diseases, is endemic in more than 70 countries. However, the clinical diagnosis of patients with a low degree of infection is an unsolved technical problem. In areas endemic for schistosomiasis japonica, proctoscopy detection of eggs has been one method used for clinical diagnosis. However, it is often a challenge to find typical live eg...

BACKGROUND Schistosoma japonicum is a major public health concern in China, with over one million people infected and another 40 million living in areas at risk of infection. Unlike the disease caused by S. mansoni and S. haematobium, schistosomiasis japonica is a zoonosis, involving a number of different mammalian species as reservoir hosts. As a result of a number of published reports from Ch...

We tested effects of praziquantel, an antischistosomal compound, on clinical and immunological parameters of chronic schistosomiasis japonica. Two Japanese patients, who had high antibody titers to Schistosoma japonicum antigens but no fecal schistosome eggs or no or mild symptoms complained, were treated with praziquantel. Within two years after treatment, anti-schistosome antibodies in sera f...

Schistosomiasis japonica is a major parasitic disease threatening millions of people in China. Though overall prevalence was greatly reduced during the second half of the past century, continued persistence in some areas and cases of re-emergence in others remain major concerns. As many regions in China are approaching disease elimination, obtaining quantitative data on Schistosoma japonicum pa...

Abstract: Schistosomiasis is a disease caused by worm Schistosoma japonicum which requires an intermediate animal, namely snail called Oncomelania Hupensis Lindoensis. In the work area Health Care Canter of Wuasa, still many cases, because most population are immigrants, they open rice fields and plantations in focus snail. The purpose was to determine relationship between knowledge attitudes w...

Schistosoma japonicum, the only schistosome species in the Philippines, was first described in 1906 among patients at the Philippines General Hospital and among inmates of a Manila prison [1]. In 1937, Onchomelania quadrasi was identified as the intermediate host of S. japonicum in the Philippines, and mapping projects to locate transmission sites commenced. Such studies revealed that schistoso...