Mutations in the tumor suppressor gene NF2 lead to Neurofibromatosis type 2 (NF2), a tumor predisposition syndrome characterized by the development of schwannomas, including bilateral vestibular schwannomas with complete penetrance. Recent work has implicated the importance of COX-2 in schwannoma growth. Using a genetically engineered murine model of NF2, we demonstrate that selective inhibitio...

Among posterior fossa tumours, schwannomas arising from glossopharyngeal nerves are extremely rare, and only 39 cases of glossopharyngeal schwannomas have been described. The clinical and imaging features of glossopharyngeal schwannomas closely resemble that of acoustic schwannomas. Despite its accuracy, magnetic resonance imaging is not diagnostic of a ninth nerve schwannoma. This is because t...

Intraspinal schwannomas localized in the sacrum are relatively infrequent, accounting for 1-5% of all spinal axis schwannomas. They frequently grow to considerable size before detection; hence, the term giant sacral schwannoma. Sacral schwannomas arise from the sacral nerve roots. The diagnosis of schwannomas in the spinal canal is difficult because of their slow growth, often resulting in exte...

Introduction. Schwannomas of the head and neck develop from the sheaths of cranial, peripheral or autonomic nerves. Between 25% and 45% of schwannomas occur in this region. Schwannomas of the sympathetic chain are very rare, and the literature describes just over 40 cases, localised mostly in the neck or retroperitoneal areas. Case report. We present the case of a 38 year-old woman with a large...

Schwannomas are benign encapsulated tumors arising from Schwann cells in the peripheral nervous system. Between 25 and 45% of schwannomas occur in the head and neck region. Schwannomas of the larynx are extremely rare with an incidence of 0.1-1.5% in all benign laryngeal tumors. Laryngeal schwannomas usually occur in females aged between their 4th and 5th decades. The most successful curative m...

Approximately 25-40% of the total schwannomas, are head and neck Schwannomas, they may originate from nerve sheath peripheral, cranial or autonomic nerves. We report a case Schwannoma right side Submandibular region in 25 year old female with no significant dental, personal medical history. Schwannomas slowly progressive benign lesions, patient presents mass swelling that is growing size slowly...

This case report illustrates two unusual cases of parapharyngeal schwannomas mimicking carotid body tumors in terms of characteristic vascular displacement. Carotid body tumors classically cause splaying of internal and external carotid arteries demonstrating the Lyre sign on imaging. Also interestingly, both of these cases were seen in younger ages and include cervical sympathetic chain schwan...

Schwannomatosis is a rare tumor syndrome characterized by the presence of multiple benign non-vestibular, non-intradermal schwannomas and by the absence of neurofibromatosis type 1 or 2 syndromes. Multiple schwannomas are clinically and genetically distinct from neurofibromatosis, and the main treatment in case of symptomatic lesions is represented by surgical resection. In case of asymptomatic...