Chitinase-3-like protein 1 (YKL-40) is suggested to be associated with type 2 T helper response and atopy. The aim of the study was the evaluation of serum YKL-40 level in atopic dermatitis. The study was performed on 59 patients: 27 males and 32 females, aged from 18 to 64 years. The severity of the disease was assessed by the SCORAD and objective SCORAD indexes. The severity of pruritus was m...

b ac k gro und : atopic dermatitis (ad) is a prevalent chronic disease in children aging from 6 months to 12 years old. recent studies have shown a positive effect of prebiotics in the prevention and treatment of ad. the mechanism of this effect has not been clearly established. the objective of this study was to investigate the effect of supplementation of prebiotic on serum immunoglobulin e (...

BACKGROUND Atopic dermatitis (AD) patients may benefit from using textiles coated with skin microbiome-modulating compounds. Chitosan, a natural biopolymer with immunomodulatory and antimicrobial properties, has been considered potentially useful. OBJECTIVE This randomized controlled trial assessed the clinical utility of chitosan-coated garment use in AD. METHODS Of the 102 patients screen...

The aim of this study was to investigate the suitability and effectiveness of heliotherapy in moderate or severe atopic dermatitis in adults in the Canary Islands. A total of 216 patients participated on 6 different 2- or 3-week heliotherapy trips. Using the Severity Scoring of Atopic Dermatitis Index (SCORAD), the severity of atopic dermatitis was assessed prior to the start of heliotherapy, a...

The aim of this study was to evaluate the effect of underwear made of ethylene vinyl alcohol (EVOH) fiber in children with atopic dermatitis (AD). Twenty-one AD children (11 EVOH group and 10 control group) were studied for 4 weeks. Their AD severity based on the Scoring Atopic Dermatitis (SCORAD) score and physiological functions were assessed. The objective SCORAD significantly decreased in b...

Background: The skin of patients with atopic dermatitis has a high susceptibility to staphylococcus aureus (S. aureus) colonization known to produce toxins with super antigen (SAgs) activity which are a family of potent immune-stimulatory exotoxins and may aggravate AD. The aim of this research was to evaluate the ro...

Many patients with atopic dermatitis are dissatisfied with conventional treatments based on topical steroids and have experienced some traditional remedies and alternative therapies. However, most of such therapies have not been evaluated scientifically and clinically by specialists. This study was designed to assess whether a certain vegetarian diet might be effective for atopic dermatitis and...

BACKGROUND Balneotherapy is widely used as an alternative treatment modality for AD. Although the clinical benefit of some mineral waters has been established, their mechanisms of action in alleviating AD are only partly understood. OBJECTIVE The clinical modification and immunomodulatory or anti-inflammatory effects of mineral water from the Suanbo hot springs on the differentiation and cyto...

BACKGROUND Atopic dermatitis (AD) is an immune mediated disease with complex pathogenesis characterised by persistency, frequent exacerbations, and inefficacy of existing therapies. Damaged or weakened intestinal microbiocenosis is considered as an important aetiological factor of AD. The aim of this study was to evaluate the efficacy and safety of medical preparation Lactofiltrum (lactulose an...

BACKGROUND Vitamin D seems to influence the evolution of atopic dermatitis (AD) in children. METHODS We tested the vitamin D serum levels of 39 children with AD (AD group t0) and of 20 nonallergic healthy controls (C group). AD severity was evaluated using the AD scoring system (SCORAD index). Cytokine serum levels (IL-2, IL-4, IL-6, IFN-γ, TNF-α) and atopy biomarkers were also measured. The ...