OBJECTIVES Obesity is an important risk factor for the development of colorectal cancer (CRC). Although the impact of bariatric surgery on CRC is conflicting, its impact on precursor lesions is unknown. The aim of this study was to determine whether bariatric surgery before index screening colonoscopy is associated with decreased development of colorectal adenomas. METHODS We performed a retr...

BACKGROUND There is little knowledge about familial hypercholesterolemia in Brazil. This study presents the first results of genetic cascade screening performed in the city of Sao Paulo. MATERIAL AND METHODS Two-hundred and forty-eight suspected index cases were initially included. DNA was extracted from peripheral blood and the complete coding sequence of low-density lipoprotein receptor, ex...

OBJECTIVE Public understanding of chronic kidney disease (CKD) is important to ensure informed participation in CKD prevention programs. This study aimed to develop and to test the psychometric profile of the CKD Screening Index that measures patient's knowledge, attitudes, and practices regarding CKD prevention and early detection. METHODS A cross-sectional design was implemented and a total...

Sensitivity analysis aims at exploring which of a number of variables have an impact on a certain response. Not only are the individual variables of interest but also whether they interact or not. By analogy with the total sensitivity index, used to detect the most influential variables, a screening of interactions can be done efficiently with the so-called total interaction index (TII), define...

BACKGROUND AND OBJECTIVE Serological screening enables us to detect patients of celiac disease (CD) before they develop serious complications. This study was planned to assess the prevalence of CD in the family members of index cases by serological screening. PATIENTS AND METHODS A prospective study was conducted on 50 children diagnosed to be having CD. Serological screening of the family me...

AIM Changes in indexes of obesity, such as waist circumference (WC) and body mass index (BMI), may influence some glucose metabolism-related parameters in both obese and non-obese subjects. We have investigated the impact of changes in WC and in BMI on data related to glucose metabolism over a one-year period. METHODS Data from 3213 individuals (2014 men, 1199 women) who underwent a general h...

OBJECTIVE To evaluate the implementation of screening colonoscopy amongst first-degree relatives (FDRs) of patients with colorectal cancer (CRC) in Turkey. MATERIALS AND METHODS A total of 400 first-degree relatives (mean(SD)age: 42.5(12.7) years, 55.5% were male) of 136 CRC patients were included in this cross-sectional questionnaire based survey. Data on demographic characteristics, relatio...

This study was conducted to determine drought tolerance genotypes with superiority in different stressed environments. To screening quantitative indices of drought tolerance, genotypes of safflower (Carthamus tinctorius L.) were tested in a complete randomized block design with three replications under two different water regimes (irrigated and rainfed). Significant positive correlatio...